Title :

Prevention of influenza virus infection and transmission by intranasal administration of a porous maltodextrin nanoparticle-formulated vaccine

Author(s) :

Quan Le, Minh [Auteur]
Ye, Liang [Auteur]
Bernasconi, Valentina [Auteur]
Carpentier, Rodolphe [Auteur]
Fasquelle, Francois [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lycke, Nils [Auteur]
Staeheli, Peter [Auteur]
Betbeder, Didier [Auteur]

Journal title :

International Journal of Pharmaceutics

Abbreviated title :

Int J Pharm

Pages :

119348

Publication date :

2020-04-20

ISSN :

1873-3476

Keyword(s) :

CTA1-DD
Influenza
Nanoparticle
Vaccine
Intranasal

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Influenza vaccines administered intramuscularly exhibit poor mucosal immune responses in the respiratory tract which is the prime site of the infection. Intranasal vaccination is a potential route for vaccine delivery which ...
Show more >Influenza vaccines administered intramuscularly exhibit poor mucosal immune responses in the respiratory tract which is the prime site of the infection. Intranasal vaccination is a potential route for vaccine delivery which has been demonstrated effective in inducing protective immune responses in both systemic and mucosal compartments. For this purpose, nanoparticles have been used as antigen delivery systems to improve antigen capture by immune cells. In this paper we demonstrate efficient delivery of viral antigens to airway epithelial cells, macrophages and dendritic cells, using polysaccharide nanoparticles (NPL), leading to a strong protection against influenza virus infection. A formulation combining split Udorn virus antigens with NPL and the mucosal protein adjuvant CTA1-DD was administered intranasally and resulted in an enhanced specific humoral immune response. Furthermore, NPL carrying split Udorn, with or without CTA1-DD, inhibited virus transmission from infected to uninfected naive mice. These results demonstrate that an intranasal delivery system combining NPL, mucosal adjuvant CTA1-DD and split virus antigens confers robust protection against influenza infection and inhibits virus transmission.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2021-07-06T12:47:12Z