Title :

Quality of life was similar in children with congenital diaphragmatic hernia and oesophageal atresia and related to respiratory morbidity

Author(s) :

Darmaun, Laura [Auteur]
Pneumologie et allergologie pédiatriques [CHU Jeanne de Flandre, Lille]
Lejeune, Stephanie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Drumez, Elodie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Mur, Sebastien [Auteur]
CIC CHU ( Lille)/inserm
De Langle, Fanny [Auteur]
Pneumologie et allergologie pédiatriques [CHU Jeanne de Flandre, Lille]
Neve, Veronique [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Storme, Laurent [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Michaud, Laurent [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Thumerelle, Caroline [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Deschildre, Antoine [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Acta Paediatrica

Abbreviated title :

Acta Paediatr.

Volume number :

110

Pages :

695-703

Publication date :

2020-06-21

ISSN :

1651-2227

Keyword(s) :

congenital diaphragmatic hernia
lung function tests
oesophageal atresia
quality of life
respiratory morbidity

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To assess quality of life (QoL) in children with congenital diaphragmatic hernia (CDH) and to compare it with oesophageal atresia (OA). A cross-sectional study in CDH children (≥7 years) was conducted in Lille University ...
Show more >To assess quality of life (QoL) in children with congenital diaphragmatic hernia (CDH) and to compare it with oesophageal atresia (OA). A cross-sectional study in CDH children (≥7 years) was conducted in Lille University Hospital, France, from January 2013 to April 2014. History, lung function (rest, exercise) and Pediatric Quality of Life Inventory questionnaires (PedsQoL 4.0) were collected. Data of OA children were previously published. Fifty-four CDH patients (male: 53%, median age: 11 years, IQR 9-14) were compared to 54 OA patients (male: 61%, median age: 13 years, IQR: 11-15). CDH children had significantly more frequent history of pneumonia (30% vs 13%), exercise limitation (54% vs 35%) and chest deformity (39% vs 11%); 46% had an obstructive pattern and 66% an abnormal cardiopulmonary exercise test. The median PedsQoL total score in children was 81 (IQR 73-90) in CDH and 81 (IQR 72-91) in OA (P = .8). In CDH, duration of neonatal oxygen therapy, hospitalisation for respiratory disease, exercise limitation, inhaled corticosteroids treatment, chest deformity, abnormal cardiopulmonary exercise test and lower forced expiratory volume in one second were significantly associated with lower QoL scores. PedsQoL scores remained satisfactory in CDH children with CDH, with no difference compared to OA. Patients with respiratory morbidity and lung function impairment, who displayed lower scores, should be identified in order to optimise their management in reference centres.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2021-07-06T12:47:33Z
2022-11-29T11:37:12Z
2022-12-14T10:00:41Z