Effects of Fronto-Temporal Transcranial ...
Document type :
Article dans une revue scientifique
DOI :
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Title :
Effects of Fronto-Temporal Transcranial Direct Current Stimulation on Auditory Verbal Hallucinations and Resting-State Functional Connectivity of the Left Temporo-Parietal Junction in Patients With Schizophrenia
Author(s) :
Mondino, Marine [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Jardri, Renaud [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Suaud-Chagny, Marie-Françoise [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Saoud, Mohamed [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Poulet, Emmanuel [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Brunelin, Jérôme [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Jardri, Renaud [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Suaud-Chagny, Marie-Françoise [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Saoud, Mohamed [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Poulet, Emmanuel [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Brunelin, Jérôme [Auteur]
Centre Hospitalier le Vinatier [Bron]
Schizophrenies Débutantes et Résistantes : de la Physiopathologie à la Thérapeutique
Journal title :
Schizophrenia Bulletin
Abbreviated title :
Schizophr Bull
Volume number :
42
Pages :
318-326
Publication date :
2016-03
ISSN :
1745-1701
HAL domain(s) :
Sciences cognitives
English abstract : [en]
Auditory verbal hallucinations (AVH) in patients with schizophrenia are associated with abnormal hyperactivity in the left temporo-parietal junction (TPJ) and abnormal connectivity between frontal and temporal areas. Recent ...
Show more >Auditory verbal hallucinations (AVH) in patients with schizophrenia are associated with abnormal hyperactivity in the left temporo-parietal junction (TPJ) and abnormal connectivity between frontal and temporal areas. Recent findings suggest that fronto-temporal transcranial Direct Current stimulation (tDCS) with the cathode placed over the left TPJ and the anode over the left prefrontal cortex can alleviate treatment-resistant AVH in patients with schizophrenia. However, brain correlates of the AVH reduction are unclear. Here, we investigated the effect of tDCS on the resting-state functional connectivity (rs-FC) of the left TPJ. Twenty-three patients with schizophrenia and treatment-resistant AVH were randomly allocated to receive 10 sessions of active (2 mA, 20 min) or sham tDCS (2 sessions/d for 5 d). We compared the rs-FC of the left TPJ between patients before and after they received active or sham tDCS. Relative to sham tDCS, active tDCS significantly reduced AVH as well as the negative symptoms. Active tDCS also reduced rs-FC of the left TPJ with the left anterior insula and the right inferior frontal gyrus and increased rs-FC of the left TPJ with the left angular gyrus, the left dorsolateral prefrontal cortex and the precuneus. The reduction of AVH severity was correlated with the reduction of the rs-FC between the left TPJ and the left anterior insula. These findings suggest that the reduction of AVH induced by tDCS is associated with a modulation of the rs-FC within an AVH-related brain network, including brain areas involved in inner speech production and monitoring.Show less >
Show more >Auditory verbal hallucinations (AVH) in patients with schizophrenia are associated with abnormal hyperactivity in the left temporo-parietal junction (TPJ) and abnormal connectivity between frontal and temporal areas. Recent findings suggest that fronto-temporal transcranial Direct Current stimulation (tDCS) with the cathode placed over the left TPJ and the anode over the left prefrontal cortex can alleviate treatment-resistant AVH in patients with schizophrenia. However, brain correlates of the AVH reduction are unclear. Here, we investigated the effect of tDCS on the resting-state functional connectivity (rs-FC) of the left TPJ. Twenty-three patients with schizophrenia and treatment-resistant AVH were randomly allocated to receive 10 sessions of active (2 mA, 20 min) or sham tDCS (2 sessions/d for 5 d). We compared the rs-FC of the left TPJ between patients before and after they received active or sham tDCS. Relative to sham tDCS, active tDCS significantly reduced AVH as well as the negative symptoms. Active tDCS also reduced rs-FC of the left TPJ with the left anterior insula and the right inferior frontal gyrus and increased rs-FC of the left TPJ with the left angular gyrus, the left dorsolateral prefrontal cortex and the precuneus. The reduction of AVH severity was correlated with the reduction of the rs-FC between the left TPJ and the left anterior insula. These findings suggest that the reduction of AVH induced by tDCS is associated with a modulation of the rs-FC within an AVH-related brain network, including brain areas involved in inner speech production and monitoring.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Research team(s) :
Équipe Psychiatrie & Croyance (PsyCHIC)
Submission date :
2019-02-13T14:48:09Z
2020-01-23T07:50:16Z
2020-03-23T14:02:31Z
2020-01-23T07:50:16Z
2020-03-23T14:02:31Z
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