Clinical and neurocognitive aspects of ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Clinical and neurocognitive aspects of hallucinations in Alzheimer’s disease
Author(s) :
El Haj, Mohamad [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Roche, Jean [Auteur]
Jardri, Renaud [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Kapogiannis, Dimitrios [Auteur]
Gallouj, Karim [Auteur]
Antoine, Pascal [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Roche, Jean [Auteur]
Jardri, Renaud [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Kapogiannis, Dimitrios [Auteur]
Gallouj, Karim [Auteur]
Antoine, Pascal [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Journal title :
Neuroscience & Biobehavioral Reviews
Abbreviated title :
Neuroscience & Biobehavioral Reviews
Volume number :
83
Pages :
713-720
Publication date :
2017-02-21
ISSN :
0149-7634
HAL domain(s) :
Sciences cognitives
English abstract : [en]
Due to their prevalence, hallucinations are considered as one of the most frequent psychotic symptoms in Alzheimer’s disease (AD). These psychotic manifestations reduce patients’ well-being, increase the burden of caregivers, ...
Show more >Due to their prevalence, hallucinations are considered as one of the most frequent psychotic symptoms in Alzheimer’s disease (AD). These psychotic manifestations reduce patients’ well-being, increase the burden of caregivers, contribute to early institutionalization, and are related with the course of cognitive decline in AD. Considering their consequences, we provide a comprehensive account of the current state of knowledge about the prevalence and characteristics of hallucinations in AD. We propose a comprehensive and testable theoretical model about hallucinations in AD: the ALZHA (ALZheimer and HAllucinations) model. In this model, neurological, genetic, cognitive, affective, and iatrogenic factors associated with hallucinations in AD are highlighted. According to the ALZHA model, hallucinations in AD first involve trait markers (i.e., cognitive deficits, neurological deficits, genetic predisposition and/or sensory deficits) to which state markers that may trigger these experiences are added (e.g., psychological distress and/or iatrogenic factors). Finally, we provide recommendations for assessment and management of these psychotic manifestations in AD, with the aim to benefit patients, caregivers, and health professionals.Show less >
Show more >Due to their prevalence, hallucinations are considered as one of the most frequent psychotic symptoms in Alzheimer’s disease (AD). These psychotic manifestations reduce patients’ well-being, increase the burden of caregivers, contribute to early institutionalization, and are related with the course of cognitive decline in AD. Considering their consequences, we provide a comprehensive account of the current state of knowledge about the prevalence and characteristics of hallucinations in AD. We propose a comprehensive and testable theoretical model about hallucinations in AD: the ALZHA (ALZheimer and HAllucinations) model. In this model, neurological, genetic, cognitive, affective, and iatrogenic factors associated with hallucinations in AD are highlighted. According to the ALZHA model, hallucinations in AD first involve trait markers (i.e., cognitive deficits, neurological deficits, genetic predisposition and/or sensory deficits) to which state markers that may trigger these experiences are added (e.g., psychological distress and/or iatrogenic factors). Finally, we provide recommendations for assessment and management of these psychotic manifestations in AD, with the aim to benefit patients, caregivers, and health professionals.Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Research team(s) :
Équipe Dynamique Émotionnelle et Pathologies (DEEP)
Équipe Psychiatrie & Croyance (PsyCHIC)
Équipe Psychiatrie & Croyance (PsyCHIC)
Submission date :
2019-02-13T14:48:22Z
2019-12-03T16:03:38Z
2019-12-03T16:07:45Z
2021-05-20T14:27:40Z
2019-12-03T16:03:38Z
2019-12-03T16:07:45Z
2021-05-20T14:27:40Z