Synthetic cathinones: a new public health problem
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Synthetic cathinones: a new public health problem
Author(s) :
Karila, Laurent [Auteur]
Hôpital Paul Brousse
Megarbane, Bruno [Auteur]
Variabilité de réponse aux Psychotropes [VariaPsy - U1144]
Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière]
Cottencin, Olivier [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Lejoyeux, Michel [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Hôpital Paul Brousse
Megarbane, Bruno [Auteur]
Variabilité de réponse aux Psychotropes [VariaPsy - U1144]
Service de Réanimation Médicale et Toxicologique [Hôpital Lariboisière]
Cottencin, Olivier [Auteur]
Laboratoire Sciences Cognitives et Sciences Affectives - UMR 9193 [SCALab]
Lejoyeux, Michel [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Journal title :
Current Neuropharmacology
Abbreviated title :
Curr Neuropharmacol
Volume number :
13
Pages :
12-20
Publication date :
2015-01
ISSN :
1570-159X
English keyword(s) :
Addiction
MDPV
4-MEC
mephedrone
methylone
new psychoactive substances
substance use disorder
substituted cathinones
synthetic cathinones
MDPV
4-MEC
mephedrone
methylone
new psychoactive substances
substance use disorder
substituted cathinones
synthetic cathinones
HAL domain(s) :
Sciences cognitives
English abstract : [en]
New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often ...
Show more >New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamphetamine (MDMA, ecstasy), and methamphetamine. The overwhelming majority of synthetic cathinones are produced in China and South East Asian countries. The Internet has emerged as the new marketplace for NPS, playing a major role in providing information on acquisition, synthesis, extraction, identification, and substance use. All these compounds are intentionally mislabeled and sold on-line under slang terms such as bath salts, plant food, plant feeders and research chemicals. They are sometimes labeled « not for human use » or « not tested for hazards or toxicity ». The rapid spread of NPS forces member countries of the European Union to adapt their response to the potential new dangers that may cause. To date, not only health actors but also the general public need to be clearly informed and aware of dangers resulting from NPS spread and use. Here, we review the major clinical effects of synthetic cathinones to highlight their impact on public health. A literature search was conducted from 2009 to 2014 based on PubMed, Google Scholar, Erowid, and governmental websites, using the following keywords alone or in combination: "new psychoactive substances", "synthetic cathinones", "substituted cathinones", "mephedrone", "methylone", "MDPV", "4-MEC", "addiction", and "substance use disorder".Show less >
Show more >New psychoactive substances (NPS) have completely modified the drug scene and the current landscape of addiction. Synthetic substances, such as substituted or synthetic cathinones, also known as « legal highs », are often produced and used to mimic the effects of controlled drugs such as cocaine, methylenedioxymethamphetamine (MDMA, ecstasy), and methamphetamine. The overwhelming majority of synthetic cathinones are produced in China and South East Asian countries. The Internet has emerged as the new marketplace for NPS, playing a major role in providing information on acquisition, synthesis, extraction, identification, and substance use. All these compounds are intentionally mislabeled and sold on-line under slang terms such as bath salts, plant food, plant feeders and research chemicals. They are sometimes labeled « not for human use » or « not tested for hazards or toxicity ». The rapid spread of NPS forces member countries of the European Union to adapt their response to the potential new dangers that may cause. To date, not only health actors but also the general public need to be clearly informed and aware of dangers resulting from NPS spread and use. Here, we review the major clinical effects of synthetic cathinones to highlight their impact on public health. A literature search was conducted from 2009 to 2014 based on PubMed, Google Scholar, Erowid, and governmental websites, using the following keywords alone or in combination: "new psychoactive substances", "synthetic cathinones", "substituted cathinones", "mephedrone", "methylone", "MDPV", "4-MEC", "addiction", and "substance use disorder".Show less >
Language :
Anglais
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
CHU Lille
CNRS
CHU Lille
Research team(s) :
Équipe Psychiatrie & Croyance (PsyCHIC)
Submission date :
2019-02-13T14:50:46Z
2020-04-14T13:28:14Z
2020-04-14T13:28:14Z