Vancomycin Functionalized Nanoparticles ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
Vancomycin Functionalized Nanoparticles for Bactericidal Biomaterial Surfaces
Author(s) :
Pichavant, Loic [Auteur]
Carrie, Helene [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Minh Ngoc, Nguyen [Auteur]
Plawinski, Laurent [Auteur]
Durrieu, Marie-Christine [Auteur]
Heroguez, Valerie [Auteur]
Carrie, Helene [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Minh Ngoc, Nguyen [Auteur]
Plawinski, Laurent [Auteur]
Durrieu, Marie-Christine [Auteur]
Heroguez, Valerie [Auteur]
Journal title :
Biomacromolecules
Abbreviated title :
Biomacromolecules
Volume number :
17
Pages :
1339-1346
Publication date :
2016
HAL domain(s) :
Sciences du Vivant [q-bio]
French abstract :
In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy ...
Show more >In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of α-norbornenyl-ω-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.Show less >
Show more >In this paper, we describe a simple and powerful way to synthesize antibacterial biomaterials with applications as implants in orthopedic surgery. Such implants are obtained by covalently grafting onto the Ti90A16 V4 alloy surface with vancomycin-functionalized nanoparticles. Nanoparticles were produced by ring-opening metathesis polymerization of α-norbornenyl-ω-vancomycin poly(ethylene oxide) macromonomers. Vancomycin is an interesting candidate because of its use in the field of implant associated infection as it is a glycopeptide which acts on bacterial walls. As a consequence, vancomycin does not need to be released for it to be active. In the first part of this paper, the synthesis and the complete characterization of these materials are described. In a second part, the in vitro antibacterial behavior is analyzed and discussed.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Research team(s) :
Modélisation biopharmaceutique et pharmacocinétique
Submission date :
2019-02-26T17:11:47Z