Titre :

Dressings Loaded with Cyclodextrin-Hamamelitannin Complexes Increase Staphylococcus aureus Susceptibility Toward Antibiotics Both in Single as well as in Mixed Biofilm Communities

Auteur(s) :

Brackman, Gilles [Auteur]
Universiteit Gent = Ghent University [UGENT]
Garcia Fernandez, Maria-Jose [Auteur]
Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS]
Lenoir, Joke [Auteur]
Universiteit Gent = Ghent University [UGENT]
De Meyer, Laurens [Auteur]
Universiteit Gent = Ghent University [UGENT]
Remon, Jean-Paul [Auteur]
Universiteit Gent = Ghent University [UGENT]
De Beer, Thomas [Auteur]
Universiteit Gent = Ghent University [UGENT]
Concheiro, Angel [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]
Alvarez-Lorenzo, Carmen [Auteur]
Universidade de Santiago de Compostela [Spain] [USC ]
Coenye, Tom [Auteur]
Universiteit Gent = Ghent University [UGENT]

Titre de la revue :

Macromolecular Bioscience

Nom court de la revue :

Macromol. Biosci.

Numéro :

16

Pagination :

859-869

Date de publication :

2016-02

ISSN :

1616-5187

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS) systems to regulate biofilm formation, and QS ...
Lire la suite >Bacteria reside within biofilms at the infection site, making them extremely difficult to eradicate with conventional wound care products. Bacteria use quorum sensing (QS) systems to regulate biofilm formation, and QS inhibitors (QSIs) have been proposed as promising antibiofilm agents. Despite this, few antimicrobial therapies that interfere with QS exist. Nontoxic hydroxypropyl-β-cyclodextrin-functionalized cellulose gauzes releasing a burst of the antibiotic vancomycin and the QSI hamamelitannin are developed, followed by a sustained release of both. The gauzes affect QS and biofilm formation of Pseudomonas aeruginosa and Staphylococcus aureus in an in vitro model of chronic wound infection and can be considered as candidates to be used to prevent wound infection as well as treat infected woundsLire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Université de Lille
CHU Lille

Collections :

• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Équipe(s) de recherche :

Modélisation biopharmaceutique et pharmacocinétique

Date de dépôt :

2019-02-26T17:11:47Z
2021-12-15T09:29:04Z