Title :

Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials

Author(s) :

Pichavant, Loic [Auteur]
Laboratoire de Chimie des Polymères Organiques [LCPO]
Carrié, Hélène [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Durrieu, Marie-Christine [Auteur]
Chimie et Biologie des Membranes et des Nanoobjets [CBMN]
Heroguez, Valerie [Auteur]
Laboratoire de Chimie des Polymères Organiques [LCPO]

Journal title :

Polymer Chemistry

Abbreviated title :

Polym. Chem.

Volume number :

45

Pages :

7019-7028

Publication date :

2016

ISSN :

1759-9954

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the ...
Show more >Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365

Research team(s) :

Modélisation biopharmaceutique et pharmacocinétique

Submission date :

2019-02-26T17:11:52Z
2022-01-19T11:16:10Z