InteractIon of 4 allotropIc modifications ...
Type de document :
Compte-rendu et recension critique d'ouvrage
DOI :
Titre :
InteractIon of 4 allotropIc modifications of carbon nanoparticles wIth living tissues
Auteur(s) :
Paryzhak, S [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Dumych, T [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Peshkova, S [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Bila, E. [Auteur]
Lutsyk, A. [Auteur]
Barras, Alexandre [Auteur]
Bilyy, Rostyslav [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Szunerits, Sabine [Auteur]
Institut Supérieur de l'Electronique et du Numérique - Lille [ISEN-Lille]
Boukherroub, Rabah [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Dumych, T [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Peshkova, S [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Bila, E. [Auteur]
Lutsyk, A. [Auteur]
Barras, Alexandre [Auteur]
Bilyy, Rostyslav [Auteur]
Danylo Halytsky Lviv National Medical University [Lviv, Ukraine]
Szunerits, Sabine [Auteur]
Institut Supérieur de l'Electronique et du Numérique - Lille [ISEN-Lille]
Boukherroub, Rabah [Auteur]
NanoBioInterfaces - IEMN [NBI - IEMN]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Titre de la revue :
The Ukrainian Biochemical Journal
Pagination :
41-50
Éditeur :
National Academy of Sciences of Ukraine (NASU)
Date de publication :
2019
ISSN :
2409-4943
Mot(s)-clé(s) en anglais :
carbon-based nanostructures
inflammation
immune response
neutrophil extracellular traps (NETs)
inflammation
immune response
neutrophil extracellular traps (NETs)
Discipline(s) HAL :
Sciences du Vivant [q-bio]/Toxicologie
Sciences du Vivant [q-bio]/Ecologie, Environnement/Santé
Sciences du Vivant [q-bio]/Immunologie
Sciences du Vivant [q-bio]/Ecologie, Environnement/Santé
Sciences du Vivant [q-bio]/Immunologie
Résumé en anglais : [en]
Environmental pollution and technological progress lead to carbon nanoparticles that pose a serious health risk. They are present in soot, dust, and printing toner and can also be formed during grinding and cutting. human ...
Lire la suite >Environmental pollution and technological progress lead to carbon nanoparticles that pose a serious health risk. They are present in soot, dust, and printing toner and can also be formed during grinding and cutting. human neutrophils are able to sequester foreign material by formation of neutrophil extracellular traps (NETs), a process that can cause a strong inflammatory response. In the current work we compared pro-inflammatory properties of different carbon-based nanostructures: nanodiamonds, graphene oxide, fullere-nes c 60 and carbon dots. We tested adjuvant properties of carbon nanoparticles in a murine immunization model by investigating humoral (specific IgG and IgM antibodies) and cellular (delayed type hypersensitivity) immune responses. The ability of NETs to sequester nanoparticles was analyzed in a mouse air pouch model and neutrophil activation was verified by in vivo tracking of near-infrared labeled nanodiamonds and ex vivo fluorescent assays using human blood-derived neutrophils. All carbon nanoparticles exhibited proinflam-matory adjuvant-like properties by stimulating production of specific IgG but not IgM antibodies (humoral immune response). The adjuvant-like response decreased in this order: from nanodiamonds, graphene oxide, fullerenes c 60 to carbon dots. None of the studied carbon nanoparticles triggered a delayed type hypersensi-tivity reaction (cellular immune response). Nanodiamonds and fullerenes c 60 were sequestrated in the body by NETs, as confirmed in the air pouch model and by in vivo fluorescent tracking of near-infrared labeled nanodiamonds.Lire moins >
Lire la suite >Environmental pollution and technological progress lead to carbon nanoparticles that pose a serious health risk. They are present in soot, dust, and printing toner and can also be formed during grinding and cutting. human neutrophils are able to sequester foreign material by formation of neutrophil extracellular traps (NETs), a process that can cause a strong inflammatory response. In the current work we compared pro-inflammatory properties of different carbon-based nanostructures: nanodiamonds, graphene oxide, fullere-nes c 60 and carbon dots. We tested adjuvant properties of carbon nanoparticles in a murine immunization model by investigating humoral (specific IgG and IgM antibodies) and cellular (delayed type hypersensitivity) immune responses. The ability of NETs to sequester nanoparticles was analyzed in a mouse air pouch model and neutrophil activation was verified by in vivo tracking of near-infrared labeled nanodiamonds and ex vivo fluorescent assays using human blood-derived neutrophils. All carbon nanoparticles exhibited proinflam-matory adjuvant-like properties by stimulating production of specific IgG but not IgM antibodies (humoral immune response). The adjuvant-like response decreased in this order: from nanodiamonds, graphene oxide, fullerenes c 60 to carbon dots. None of the studied carbon nanoparticles triggered a delayed type hypersensi-tivity reaction (cellular immune response). Nanodiamonds and fullerenes c 60 were sequestrated in the body by NETs, as confirmed in the air pouch model and by in vivo fluorescent tracking of near-infrared labeled nanodiamonds.Lire moins >
Langue :
Anglais
Vulgarisation :
Non
Projet Européen :
Source :
Fichiers
- https://hal.archives-ouvertes.fr/hal-02434281/document
- Accès libre
- Accéder au document
- http://ukrbiochemjournal.org/wp-content/uploads/2019/04/Paryzhak_2_19.pdf
- Accès libre
- Accéder au document
- https://hal.archives-ouvertes.fr/hal-02434281/document
- Accès libre
- Accéder au document
- https://hal.archives-ouvertes.fr/hal-02434281/document
- Accès libre
- Accéder au document
- document
- Accès libre
- Accéder au document
- 2019%20UBJ%204%20allotropic%20Carbons.pdf
- Accès libre
- Accéder au document
- Paryzhak_2_19.pdf
- Accès libre
- Accéder au document