Title :

Gel-forming mucins structure governs mucus gels viscoelasticity.

Author(s) :

Demouveaux, Bastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Gouyer, Valerie [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Magnien, Mylene [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Plet, Ségolène [Auteur]
Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286
Lille Inflammation Research International Center - U 995 [LIRIC]
Gottrand, fréderic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Lille Inflammation Research International Center - U 995 [LIRIC]
Narita, Tetsuharu [Auteur]
Desseyn, Jean-Luc [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Medecine sciences

Abbreviated title :

Med Sci (Paris)

Volume number :

34

Pages :

806-812

Publication date :

2018-10-01

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Mucus is the first line of innate mucosal defense in all mammals. Gelforming mucins control the rheological properties of mucus hydrogels by forming a network in which hydrophilic and hydrophobic regions coexist, and ...
Show more >Mucus is the first line of innate mucosal defense in all mammals. Gelforming mucins control the rheological properties of mucus hydrogels by forming a network in which hydrophilic and hydrophobic regions coexist, and it has been revealed that the network is formed through both covalent links and reversible links such as hydrophobic interactions in order to modulate the structure as a function of the physiological necessities. Here, we review the structure and functions of the mucus in terms of the gel-forming mucins protein-protein interactions, also called interactome. Since it is difficult to characterize the low energy reversible interactions due to their dependence on physico-chemical environment, their role is not well understood. Still, they constitute a promising target to counteract mucus abnormalities observed in mucus-associated diseases.Show less >

Language :

Français

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Nutritional modulation of inflammation and infection

Submission date :

2019-03-01T14:07:46Z
2019-06-06T09:47:59Z
2019-06-06T09:51:50Z
2019-06-06T09:58:51Z
2021-05-14T10:50:01Z