Diet as moderator in the association of ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Diet as moderator in the association of adiposity with inflammatory biomarkers among adolescents in the HELENA study.
Auteur(s) :
Arouca, Aline [Auteur]
Moreno Luis, A [Auteur]
Gonzalez-Gil Esther, M [Auteur]
Marcos, Ascension [Auteur]
Widhalm, Kurt [Auteur]
Molnar, Denes [Auteur]
Manios, Yannis [Auteur]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Kafatos, Anthony [Auteur]
Kersting, Mathilde [Auteur]
Sjostrom, Michael [Auteur]
Amaro-Gahete Francisco, Jose [Auteur]
Ferrari, Marika [Auteur]
Huybrechts, Inge [Auteur]
International Agency for Cancer Research [IACR]
Gonzalez-Gross, Marcela [Auteur]
De Henauw, Stefaan [Auteur]
Michels, Nathalie [Auteur]
Moreno Luis, A [Auteur]
Gonzalez-Gil Esther, M [Auteur]
Marcos, Ascension [Auteur]
Widhalm, Kurt [Auteur]
Molnar, Denes [Auteur]
Manios, Yannis [Auteur]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Kafatos, Anthony [Auteur]
Kersting, Mathilde [Auteur]
Sjostrom, Michael [Auteur]
Amaro-Gahete Francisco, Jose [Auteur]
Ferrari, Marika [Auteur]
Huybrechts, Inge [Auteur]
International Agency for Cancer Research [IACR]
Gonzalez-Gross, Marcela [Auteur]
De Henauw, Stefaan [Auteur]
Michels, Nathalie [Auteur]
Titre de la revue :
European Journal of Nutrition
Nom court de la revue :
Eur. J. Nutr.
Numéro :
58
Pagination :
1947–1960
Date de publication :
2019-08-01
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
AIM: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. METHODS: In 618 ...
Lire la suite >AIM: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. METHODS: In 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFbeta-1, C-reactive protein, TNF-alpha, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. RESULTS: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFbeta-1, GGT, and ALT. CONCLUSION: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.Lire moins >
Lire la suite >AIM: Our aim is to demonstrate that a healthy diet might reduce the relation between adiposity and inflammation, whereas an unhealthy diet may increase the effect of adiposity on inflammatory biomarkers. METHODS: In 618 adolescents (13-17 years) of the European HELENA study, data were available on body composition, a set of inflammation markers, and food intake determined by a self-administered computerized 24-h recall. A 9-point Mediterranean diet score and an antioxidant-rich diet score were used as dietary parameters and tested as moderator. Total body fat was represented by the sum of six skinfold thicknesses and central adiposity by waist circumference. A set of inflammation-related biomarkers was used as outcome: a pro/anti-inflammatory interleukins ratio, TGFbeta-1, C-reactive protein, TNF-alpha, 3 cell adhesion molecules, and 3 types of immune cells; gamma-glutamyltransferase (GGT) and homocysteine were used as cardiovascular disease risk biomarkers, and alanine transaminase (ALT) as liver dysfunction biomarker. Multiple linear regression analyses tested moderation by diet in the adiposity-inflammation association and were adjusted for age, sex, country, puberty, socioeconomic status. RESULTS: Both the Mediterranean and antioxidant-rich diet, and overall and central adiposity, were important in the moderation. Diet was a significant protective moderator in the effect of adiposity on the pro/anti-inflammatory interleukins ratio, TGFbeta-1, GGT, and ALT. CONCLUSION: In conclusion, in some cases, a diet rich in antioxidants and essential nutrients may attenuate the concentration of inflammatory biomarkers caused by adiposity, whereas a poor diet appears to contribute to the onset of early oxidative stress signs.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Équipe(s) de recherche :
Nutritional modulation of inflammation and infection
Date de dépôt :
2019-03-01T14:08:04Z
2024-01-24T17:43:49Z
2024-01-24T17:43:49Z