Lower Respiratory Tract Infection and ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Lower Respiratory Tract Infection and Short-Term Outcome in Patients With Acute Respiratory Distress Syndrome.
Auteur(s) :
Zampieri Fernando, G [Auteur]
Povoa, Pedro [Auteur]
Salluh Jorge, I [Auteur]
Rodriguez, Alejandro [Auteur]
Valade, Sandrine [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Andrade Gomes, Jose [Auteur]
Reignier, Jean [Auteur]
Molinos, Elena [Auteur]
Almirall, Jordi [Auteur]
Boussekey, Nicolas [Auteur]
Socias, Lorenzo [Auteur]
Ramirez, Paula [Auteur]
Viana William, N [Auteur]
Rouze, Anahita [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Martin-Loeches, Ignacio [Auteur]
Povoa, Pedro [Auteur]
Salluh Jorge, I [Auteur]
Rodriguez, Alejandro [Auteur]
Valade, Sandrine [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Andrade Gomes, Jose [Auteur]
Reignier, Jean [Auteur]
Molinos, Elena [Auteur]
Almirall, Jordi [Auteur]
Boussekey, Nicolas [Auteur]
Socias, Lorenzo [Auteur]
Ramirez, Paula [Auteur]
Viana William, N [Auteur]
Rouze, Anahita [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Martin-Loeches, Ignacio [Auteur]
Titre de la revue :
Journal of Intensive Care Medicine
Nom court de la revue :
Intensive Care Med.
Numéro :
35
Pagination :
588-594
Date de publication :
2020-06-01
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
OBJECTIVE: To assess whether ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with mortality in critically ill patients with acute respiratory distress syndrome (ARDS). MATERIALS AND ...
Lire la suite >OBJECTIVE: To assess whether ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with mortality in critically ill patients with acute respiratory distress syndrome (ARDS). MATERIALS AND METHODS: Post hoc analysis of prospective cohort study including mechanically ventilated patients from a multicenter prospective observational study (TAVeM study); VA-LRTI was defined as either ventilator-associated tracheobronchitis (VAT) or ventilator-associated pneumonia (VAP) based on clinical criteria and microbiological confirmation. Association between intensive care unit (ICU) mortality in patients having ARDS with and without VA-LRTI was assessed through logistic regression controlling for relevant confounders. Association between VA-LRTI and duration of mechanical ventilation and ICU stay was assessed through competing risk analysis. Contribution of VA-LRTI to a mortality model over time was assessed through sequential random forest models. RESULTS: The cohort included 2960 patients of which 524 fulfilled criteria for ARDS; 21% had VA-LRTI (VAT = 10.3% and VAP = 10.7%). After controlling for illness severity and baseline health status, we could not find an association between VA-LRTI and ICU mortality (odds ratio: 1.07; 95% confidence interval: 0.62-1.83; P = .796); VA-LRTI was also not associated with prolonged ICU length of stay or duration of mechanical ventilation. The relative contribution of VA-LRTI to the random forest mortality model remained constant during time. The attributable VA-LRTI mortality for ARDS was higher than the attributable mortality for VA-LRTI alone. CONCLUSION: After controlling for relevant confounders, we could not find an association between occurrence of VA-LRTI and ICU mortality in patients with ARDS.Lire moins >
Lire la suite >OBJECTIVE: To assess whether ventilator-associated lower respiratory tract infections (VA-LRTIs) are associated with mortality in critically ill patients with acute respiratory distress syndrome (ARDS). MATERIALS AND METHODS: Post hoc analysis of prospective cohort study including mechanically ventilated patients from a multicenter prospective observational study (TAVeM study); VA-LRTI was defined as either ventilator-associated tracheobronchitis (VAT) or ventilator-associated pneumonia (VAP) based on clinical criteria and microbiological confirmation. Association between intensive care unit (ICU) mortality in patients having ARDS with and without VA-LRTI was assessed through logistic regression controlling for relevant confounders. Association between VA-LRTI and duration of mechanical ventilation and ICU stay was assessed through competing risk analysis. Contribution of VA-LRTI to a mortality model over time was assessed through sequential random forest models. RESULTS: The cohort included 2960 patients of which 524 fulfilled criteria for ARDS; 21% had VA-LRTI (VAT = 10.3% and VAP = 10.7%). After controlling for illness severity and baseline health status, we could not find an association between VA-LRTI and ICU mortality (odds ratio: 1.07; 95% confidence interval: 0.62-1.83; P = .796); VA-LRTI was also not associated with prolonged ICU length of stay or duration of mechanical ventilation. The relative contribution of VA-LRTI to the random forest mortality model remained constant during time. The attributable VA-LRTI mortality for ARDS was higher than the attributable mortality for VA-LRTI alone. CONCLUSION: After controlling for relevant confounders, we could not find an association between occurrence of VA-LRTI and ICU mortality in patients with ARDS.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Équipe(s) de recherche :
Fungal associated invasive and inflammatory diseases
Date de dépôt :
2019-03-01T14:08:12Z
2021-10-27T13:55:31Z
2023-12-04T15:22:40Z
2023-12-04T15:24:42Z
2021-10-27T13:55:31Z
2023-12-04T15:22:40Z
2023-12-04T15:24:42Z
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- zampieri-et-al-2018-lower-respiratory-tract-infection-and-short-term-outcome-in-patients-with-acute-respiratory.pdf
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