Title :

The ITGAV Rs3738919-C Allele Is Associated with Rheumatoid Arthritis in the European Caucasian Population: A Family-Based Study

Author(s) :

Jacq, L. [Auteur]
Garnier, S. [Auteur]
Laboratoire de recherche européen pour la polyarthrite rhumatoïde [GenHotel]
Dieudé, P. [Auteur]
Laboratoire de recherche européen pour la polyarthrite rhumatoïde [GenHotel]
Michou, L. [Auteur]
Laboratoire de recherche européen pour la polyarthrite rhumatoïde [GenHotel]
Pierlot, C. [Auteur]
Laboratoire de Chimie Organique et Macromoleculaire [UMR CNRS 8009]
Migliorini, P. [Auteur]
Balsa, A. [Auteur]
Westhovens, R. [Auteur]
Barrera, P. [Auteur]
Alves, H. [Auteur]
Vaz, C. [Auteur]
Fernandes, M. [Auteur]
Pascual-Salcedo, D. [Auteur]
Bombardieri, S. [Auteur]
Dequeker, J. [Auteur]
Radstake, T.R. [Auteur]
Van Riel, P. [Auteur]
Putte, L. [Auteur]
Lopes-Vaz, A. [Auteur]
Glikmans, E. [Auteur]
Barbet, S. [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Lasbleiz, S. [Auteur]
Lemaire, I. [Auteur]
Quillet, P. [Auteur]
Hilliquin, P. [Auteur]
Teixeira, V.H. [Auteur]
Petit-Teixeira, Elisabeth [Auteur]
Laboratoire de recherche européen pour la polyarthrite rhumatoïde [GenHotel]
Mbarek, H. [Auteur]
Prum, B. [Auteur]
Laboratoire de Biométrie et Biologie Evolutive - UMR 5558 [LBBE]
Bardin, T. [Auteur]
Cornélis, François [Auteur]
Laboratoire de recherche européen pour la polyarthrite rhumatoïde [GenHotel]

Publisher :

BioMed Central

Publication date :

2007

HAL domain(s) :

Sciences du Vivant [q-bio]/Génétique/Génétique humaine

English abstract : [en]

The integrin αvβ3, whose αv subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA ...
Show more >The integrin αvβ3, whose αv subunit is encoded by the ITGAV gene, plays a key role in angiogenesis. Hyperangiogenesis is involved in rheumatoid arthritis (RA) and the ITGAV gene is located in 2q31, one of the suggested RA susceptibility loci. Our aim was to test the ITGAV gene for association and linkage to RA in a family-based study from the European Caucasian population. Two single nucleotide polymorphisms were genotyped by PCR-restriction fragment length polymorphism in 100 French Caucasian RA trio families (one RA patient and both parents), 100 other French families and 265 European families available for replication. The genetic analyses for association and linkage were performed using the comparison of allelic frequencies (affected family-based controls), the transmission disequilibrium test, and the genotype relative risk. We observed a significant RA association for the C allele of rs3738919 in the first sample (affected family-based controls, RA index cases 66.5% versus controls 56.7%; P = 0.04). The second sample showed the same trend, and the third sample again showed a significant RA association. When all sets were combined, the association was confirmed (affected family-based controls, RA index cases 64.6% versus controls 58.1%; P = 0.005). The rs3738919-C allele was also linked to RA (transmission disequilibrium test, 56.5% versus50% of transmission; P = 0.009) and the C-allele-containing genotype was more frequent in RA index cases than in controls (RA index cases 372 versus controls 339; P = 0.002, odds ratio = 1.94, 95% confidence interval = 1.3-2.9). The rs3738919-C allele of the ITGAV gene is associated with RA in the European Caucasian population, suggesting ITGAV as a new minor RA susceptibility gene. © 2007 Jacq et al.; licensee BioMed Central Ltd.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Related reference(s) :

https://www.scopus.com/inward/record.uri?eid=2-s2.0-41649112408&doi=10.1186%2far2221&partnerID=40&md5=9754b226d516b8507bdc165f921e8624

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL

Submission date :

2021-07-27T11:11:09Z