Long-term risk of solid organ de novo ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
Long-term risk of solid organ de novo malignancies after liver transplantation: a French national study on 11226 patients.
Auteur(s) :
Seree, Olivier [Auteur]
Altieri, Mario [Auteur]
Guillaume, Elodie [Auteur]
De Mil, Remy [Auteur]
Lobbedez, Thierry [Auteur]
Université de Caen Normandie [UNICAEN]
Robinson, Philip [Auteur]
Segol, Philippe [Auteur]
Salame, Ephrem [Auteur]
Abergel, Armand [Auteur]
Boillot, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Conti, Filomena [Auteur]
Chazouilleres, Olivier [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Debette-Gratien, Maryline [Auteur]
Université de Limoges [UNILIM]
Debray, Dominique [Auteur]
Hery, Geraldine [Auteur]
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Durand, Francois [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Duvoux, Christophe [Auteur]
Francoz, Claire [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Gugenheim, Jean [Auteur]
Université de Nice Sophia-Antipolis [UNSA]
Hardwigsen, Jean [Auteur]
Houssel-Debry, Pauline [Auteur]
Jacquemin, Emmanuel [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Kamar, Nassim [Auteur]
Latournerie, Marianne [Auteur]
Université de Bourgogne [UB]
Lebray, Pascal [Auteur]
Leroy, Vincent [Auteur]
Université Grenoble Alpes [2016-2019] [UGA [2016-2019]]
Mazzola, Alessandra [Auteur]
Neau-Cransac, Martine [Auteur]
Pageaux, Georges-Philippe [Auteur]
Radenne, Sylvie [Auteur]
Saliba, Faouzi [Auteur]
Samuel, Didier [Auteur]
Vanlemmens, Claire [Auteur]
Woehl-Jaegle, Marie-Lorraine [Auteur]
Launoy, Guy [Auteur]
Dumortier, Jerome [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Altieri, Mario [Auteur]
Guillaume, Elodie [Auteur]
De Mil, Remy [Auteur]
Lobbedez, Thierry [Auteur]
Université de Caen Normandie [UNICAEN]
Robinson, Philip [Auteur]
Segol, Philippe [Auteur]
Salame, Ephrem [Auteur]
Abergel, Armand [Auteur]
Boillot, Olivier [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Conti, Filomena [Auteur]
Chazouilleres, Olivier [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Debette-Gratien, Maryline [Auteur]
Université de Limoges [UNILIM]
Debray, Dominique [Auteur]
Hery, Geraldine [Auteur]
Dharancy, Sebastien [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Durand, Francois [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Duvoux, Christophe [Auteur]
Francoz, Claire [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Gugenheim, Jean [Auteur]
Université de Nice Sophia-Antipolis [UNSA]
Hardwigsen, Jean [Auteur]
Houssel-Debry, Pauline [Auteur]
Jacquemin, Emmanuel [Auteur]
Université Paris-Sud - Paris 11 [UP11]
Kamar, Nassim [Auteur]
Latournerie, Marianne [Auteur]
Université de Bourgogne [UB]
Lebray, Pascal [Auteur]
Leroy, Vincent [Auteur]
Université Grenoble Alpes [2016-2019] [UGA [2016-2019]]
Mazzola, Alessandra [Auteur]
Neau-Cransac, Martine [Auteur]
Pageaux, Georges-Philippe [Auteur]
Radenne, Sylvie [Auteur]
Saliba, Faouzi [Auteur]
Samuel, Didier [Auteur]
Vanlemmens, Claire [Auteur]
Woehl-Jaegle, Marie-Lorraine [Auteur]
Launoy, Guy [Auteur]
Dumortier, Jerome [Auteur]
Université Claude Bernard Lyon 1 [UCBL]
Titre de la revue :
Liver Transplantation
Nom court de la revue :
Liver Transpl.
Numéro :
24
Pagination :
1425-1436
Date de publication :
2018-10
ISSN :
1527-6473
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomedecine database, the present study aimed ...
Lire la suite >De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomedecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08-2.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09-2.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68-3.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97-9.48), esophageal (SIR = 4.76; 95% CI, 3.56-6.24), lung (SIR = 2.56; 95% CI, 2.21-2.95), and lip-mouth-pharynx (SIR = 2.20; 95% CI, 1.72-2.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.Lire moins >
Lire la suite >De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomedecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08-2.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09-2.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68-3.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97-9.48), esophageal (SIR = 4.76; 95% CI, 3.56-6.24), lung (SIR = 2.56; 95% CI, 2.21-2.95), and lip-mouth-pharynx (SIR = 2.20; 95% CI, 1.72-2.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Équipe(s) de recherche :
Inflammatory digestive disease : pathophysiology and therapeutic targets developement
Date de dépôt :
2019-03-01T14:17:45Z
2024-01-30T10:01:32Z
2024-01-30T10:01:32Z