C-reactive protein and procalcitonin profile ...
Document type :
Article dans une revue scientifique
PMID :
Permalink :
Title :
C-reactive protein and procalcitonin profile in ventilator-associated lower respiratory infections.
Author(s) :
Coelho, Luis [Auteur]
Rabello, Ligia [Auteur]
Salluh, Jorge [Auteur]
Martin-Loeches, Ignacio [Auteur]
Rodriguez, Alejandro [Auteur]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Andrade Gomes, Jose [Auteur]
Povoa, Pedro [Auteur]
Rabello, Ligia [Auteur]
Salluh, Jorge [Auteur]
Martin-Loeches, Ignacio [Auteur]
Rodriguez, Alejandro [Auteur]
Nseir, Saad [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Andrade Gomes, Jose [Auteur]
Povoa, Pedro [Auteur]
Journal title :
Journal of Critical Care
Abbreviated title :
J Crit Care
Volume number :
48
Pages :
385-389
Publication date :
2018-12
Keyword(s) :
Ventilator-associated
Intensive care unit
Lower respiratory tract infections
C-reactive protein
Procalcitonin
Biomarkers
Tracheobronchitis
Pneumonia
Intensive care unit
Lower respiratory tract infections
C-reactive protein
Procalcitonin
Biomarkers
Tracheobronchitis
Pneumonia
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Purpose: Ventilator-associated tracheobronchitis (VAT) has been suggested as an intermediate process between tracheobronchial colonization and ventilator-associated pneumonia (VAP) in patients receiving mechanical ventilation. ...
Show more >Purpose: Ventilator-associated tracheobronchitis (VAT) has been suggested as an intermediate process between tracheobronchial colonization and ventilator-associated pneumonia (VAP) in patients receiving mechanical ventilation. The aim of this study was to evaluate the ability of C-reactive protein (CRP) and procalcitonin (PCT) to differentiate between VAT and VAP. Methods: Pre-planned analysis of the prospective multinational TAVeM database, performed on 2960 patients receiving mechanical ventilation for >48 h, including 689 patients with VA-LRTI. Patients with the diagnosis of VAT or VAP microbiologically documented and with one measurement of CRP and/or PCT on the day of diagnosis were included. Results: Four hundred and four patients (mean age 63 years, 298 men, ICU mortality 40%) were studied, 207 with VAT and 197 with VAP. On the day of infection diagnosis, the median CRP was elevated in both groups but significantly higher in VAP (18 mg/dL vs. 14 mg/dL, p = .001). Median PCT was also significantly higher in VAP (2.1 ng/dL vs. 0.64 ng/d L, p < .001). Both biomarkers could not help distinguish between VAT and VAP. Conclusion: Although PCT and CRP presented lower values in VAT as compared to VAP, there was a marked overlap of both biomarkers values in both VA-LRTI not allowing adequate discrimination.Show less >
Show more >Purpose: Ventilator-associated tracheobronchitis (VAT) has been suggested as an intermediate process between tracheobronchial colonization and ventilator-associated pneumonia (VAP) in patients receiving mechanical ventilation. The aim of this study was to evaluate the ability of C-reactive protein (CRP) and procalcitonin (PCT) to differentiate between VAT and VAP. Methods: Pre-planned analysis of the prospective multinational TAVeM database, performed on 2960 patients receiving mechanical ventilation for >48 h, including 689 patients with VA-LRTI. Patients with the diagnosis of VAT or VAP microbiologically documented and with one measurement of CRP and/or PCT on the day of diagnosis were included. Results: Four hundred and four patients (mean age 63 years, 298 men, ICU mortality 40%) were studied, 207 with VAT and 197 with VAP. On the day of infection diagnosis, the median CRP was elevated in both groups but significantly higher in VAP (18 mg/dL vs. 14 mg/dL, p = .001). Median PCT was also significantly higher in VAP (2.1 ng/dL vs. 0.64 ng/d L, p < .001). Both biomarkers could not help distinguish between VAT and VAP. Conclusion: Although PCT and CRP presented lower values in VAT as compared to VAP, there was a marked overlap of both biomarkers values in both VA-LRTI not allowing adequate discrimination.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Research team(s) :
Fungal associated invasive and inflammatory diseases
Submission date :
2019-03-01T14:34:30Z
2023-12-01T14:04:37Z
2023-12-01T14:04:37Z