Disease severity of proliferative lupus ...
Document type :
Article dans une revue scientifique
DOI :
PMID :
Permalink :
Title :
Disease severity of proliferative lupus nephritis in Maghrebians.
Author(s) :
Tamirou, F [Auteur]
Costedoat-Chalumeau, Nathalie [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Medkouri, G [Auteur]
Daugas, Eric [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Jourde-Chiche, Noemie [Auteur]
Aix Marseille Université [AMU]
Karras, Alexandre [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Le Guern, Veronique [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Gnemmi, Viviane [Auteur]
Jadoul, M [Auteur]
Houssiau, Frederic [Auteur]
Costedoat-Chalumeau, Nathalie [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Medkouri, G [Auteur]
Daugas, Eric [Auteur]
Université Paris Diderot - Paris 7 [UPD7]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Jourde-Chiche, Noemie [Auteur]
Aix Marseille Université [AMU]
Karras, Alexandre [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Le Guern, Veronique [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Gnemmi, Viviane [Auteur]
Jadoul, M [Auteur]
Houssiau, Frederic [Auteur]
Journal title :
Lupus
Abbreviated title :
Lupus
Volume number :
27
Pages :
1387 - 1392
Publication date :
2018-07
Keyword(s) :
outcome measures
ethnicity
Maghreb
Lupus nephritis
renal flare
ethnicity
Maghreb
Lupus nephritis
renal flare
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Objective: To study the influence of Maghrebian ethnicity on lupus nephritis.
Methods: We retrospectively reviewed the files of a cohort of 194 patients with proliferative lupus nephritis followed in seven lupus centres ...
Show more >Objective: To study the influence of Maghrebian ethnicity on lupus nephritis. Methods: We retrospectively reviewed the files of a cohort of 194 patients with proliferative lupus nephritis followed in seven lupus centres belonging to three groups: Europeans living in Belgium/France (E; n = 111); Maghrebians living in Europe, in casu Belgium/France (ME; n = 43); and Maghrebians living in Morocco (MM; n = 40). Baseline presentation was compared between these three groups but complete long-term outcome data were available only for E and ME patients. Results: At presentation, the clinical and pathological characteristics of lupus nephritis did not differ between E, ME and MM patients. Renal relapses were more common in ME patients (54%) than in E patients (29%) (P < 0.01). Time to renal flare and to end-stage renal disease was shorter in ME patients compared to E patients (P < 0.0001 and P < 0.05, respectively). While proteinuria measured at month 12 accurately predicted a serum creatinine value of less than 1 mg/dl at 7 years in E patients, this was not the case in the ME group, in whom serum creatinine at month 12 performed better. Conclusion: Despite a similar disease profile at onset, the prognosis of lupus nephritis is more severe in Maghrebians living in Europe compared to native Europeans, with a higher relapse rate.Show less >
Show more >Objective: To study the influence of Maghrebian ethnicity on lupus nephritis. Methods: We retrospectively reviewed the files of a cohort of 194 patients with proliferative lupus nephritis followed in seven lupus centres belonging to three groups: Europeans living in Belgium/France (E; n = 111); Maghrebians living in Europe, in casu Belgium/France (ME; n = 43); and Maghrebians living in Morocco (MM; n = 40). Baseline presentation was compared between these three groups but complete long-term outcome data were available only for E and ME patients. Results: At presentation, the clinical and pathological characteristics of lupus nephritis did not differ between E, ME and MM patients. Renal relapses were more common in ME patients (54%) than in E patients (29%) (P < 0.01). Time to renal flare and to end-stage renal disease was shorter in ME patients compared to E patients (P < 0.0001 and P < 0.05, respectively). While proteinuria measured at month 12 accurately predicted a serum creatinine value of less than 1 mg/dl at 7 years in E patients, this was not the case in the ME group, in whom serum creatinine at month 12 performed better. Conclusion: Despite a similar disease profile at onset, the prognosis of lupus nephritis is more severe in Maghrebians living in Europe compared to native Europeans, with a higher relapse rate.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Collections :
Research team(s) :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Submission date :
2019-03-01T14:34:42Z
2024-01-25T11:17:49Z
2024-01-25T11:17:49Z