Title :

An immunological link between Candida albicans colonization and Crohn's disease

Author(s) :

Gerard, Romain [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Sendid, Boualem [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Colombel, Jean-Frederic [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Poulain, Daniel [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Jouault, Thierry [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]

Journal title :

Critical reviews in microbiology

Abbreviated title :

Crit. Rev. Microbiol.

Volume number :

41

Pages :

135-139

Publication date :

2013-07-16

ISSN :

1040-841X

Keyword(s) :

innate/adaptive immune response
pathogen associated molecular patterns
Antigens
inflammation

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

The etiology of Crohn’s disease (CD), an autoimmune, inflammatory bowel disease (IBD) which affects approximately one million people in Europe, is still unclear. Nevertheless, it is widely accepted that CD could result ...
Show more >The etiology of Crohn’s disease (CD), an autoimmune, inflammatory bowel disease (IBD) which affects approximately one million people in Europe, is still unclear. Nevertheless, it is widely accepted that CD could result from an inappropriate inflammatory response to intestinal microorganisms in a genetically susceptible host. Most studies to date have concerned the involvement of bacteria in disease progression. In addition to bacteria, there appears to be a possible link between the commensal yeast Candida albicans and disease development. In this review, in an attempt to link the gut colonization process and the development of CD, we describe the different pathways that are involved in the progression of CD and in the host response to C. albicans, making the yeast a possible initiator of the inflammatory process observed in this IBD.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

European Project :

Fungi in the setting of inflammation, allergy and autoimmune diseases:Translating basic science into clinical practices

Administrative institution(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Research team(s) :

Inflammatory digestive disease : pathophysiology and therapeutic targets developement
Fungal associated invasive and inflammatory diseases
Nutritional modulation of inflammation and infection

Submission date :

2019-03-01T14:46:38Z
2023-05-03T09:19:35Z