Title :

Control of blood cell homeostasis in Drosophila larvae by the posterior signalling centre.

Author(s) :

Krzemien, Joanna [Auteur]
Centre de biologie du développement [CBD]
Dubois, Laurence [Auteur]
Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 [IEMN]
Département de Recherche sur l'Etat Condensé, les Atomes et les Molécules [DRECAM]
Makki, Rami [Auteur]
Meister, Marie [Auteur]
Réponse immunitaire et developpement chez les insectes [RIDI - UPR 9022]
Vincent, Alain [Auteur]
FLAveur, VIsion et Comportement du consommateur [FLAVIC]
Laboratoire de synthèse organique [DCSO]
Laboratoire Bordelais de Recherche en Informatique [LaBRI]
Crozatier, Michèle [Auteur]
Centre de biologie du développement [CBD]

Journal title :

Nature

Pages :

325-8

Publisher :

Nature Publishing Group

Publication date :

2007-03-15

ISSN :

0028-0836

Keyword(s) :

STAT Transcription Factors

English keyword(s) :

Animals
Cell Differentiation
Drosophila melanogaster
Hematopoiesis
Hematopoietic Stem Cells
Hemocytes
Homeostasis
Janus Kinases
Larva
Lymphatic System
Signal Transduction
Wasps

HAL domain(s) :

Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire

English abstract : [en]

Drosophila haemocytes (blood cells) originate from a specialized haematopoietic organ-the lymph gland. Larval haematopoietic progenitors (prohaemocytes) give rise to three types of circulating haemocytes: plasmatocytes, ...
Show more >Drosophila haemocytes (blood cells) originate from a specialized haematopoietic organ-the lymph gland. Larval haematopoietic progenitors (prohaemocytes) give rise to three types of circulating haemocytes: plasmatocytes, crystal cells and lamellocytes. Lamellocytes, which are devoted to encapsulation of large foreign bodies, only differentiate in response to specific immune threats, such as parasitization by wasps. Here we show that a small cluster of signalling cells, termed the PSC (posterior signalling centre), controls the balance between multipotent prohaemocytes and differentiating haemocytes, and is necessary for the massive differentiation of lamellocytes that follows parasitization. Communication between the PSC and haematopoietic progenitors strictly depends on the PSC-restricted expression of Collier, the Drosophila orthologue of mammalian early B-cell factor. PSC cells act, in a non-cell-autonomous manner, to maintain JAK/STAT signalling activity in prohaemocytes, preventing their premature differentiation. Serrate-mediated Notch signalling from the PSC is required to maintain normal levels of col transcription. The key role of the PSC in controlling blood cell homeostasis is reminiscent of interactions between haematopoietic progenitors and their micro-environment in vertebrates, thus further highlighting the interest of Drosophila as a model system for studying the evolution of haematopoiesis and cellular innate immunity.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Non spécifiée

Popular science :

Non

Collections :

• Institut d'Électronique, de Microélectronique et de Nanotechnologie (IEMN) - UMR 8520

Source :

Harvested from HAL