Extracorporeal photopheresis for GVHD ...
Type de document :
Article dans une revue scientifique
PMID :
URL permanente :
Titre :
Extracorporeal photopheresis for GVHD prophylaxis after reduced intensity conditioning allogeneic hematopoietic stem cell transplantation: a prospective multicenter phase 2 study
Auteur(s) :
Michallet, Mauricette [Auteur]
Sobh, Mohamad [Auteur]
Garban, Frederic [Auteur]
Bulabois, Claude-Eric [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Coiteux, Valerie [Auteur]
Dulery, Remy [Auteur]
Rohrlich, Pierre-Simon [Auteur]
Legrand, Faezeh [Auteur]
Clement, Laurence [Auteur]
Praire, Aline [Auteur]
Detrait, Marie [Auteur]
Barraco, Fiorenza [Auteur]
Nicolini Franck, Emmanuel [Auteur]
Hequet, Olivier [Auteur]
Sobh, Mohamad [Auteur]
Garban, Frederic [Auteur]
Bulabois, Claude-Eric [Auteur]
Yakoub-Agha, Ibrahim [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Coiteux, Valerie [Auteur]
Dulery, Remy [Auteur]
Rohrlich, Pierre-Simon [Auteur]
Legrand, Faezeh [Auteur]
Clement, Laurence [Auteur]
Praire, Aline [Auteur]
Detrait, Marie [Auteur]
Barraco, Fiorenza [Auteur]
Nicolini Franck, Emmanuel [Auteur]
Hequet, Olivier [Auteur]
Titre de la revue :
Leukemia & lymphoma
Nom court de la revue :
Leuk. Lymphoma
Numéro :
59
Pagination :
372-380
Date de publication :
2018-01-01
ISSN :
1042-8194
Mot(s)-clé(s) :
Extracorporeal photopheresis
Allo-HSCT
GVHD
Allo-HSCT
GVHD
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
We performed a prospective multicenter phase 2 study to evaluate the safety and efficacy of prophylactic Extracorporeal Photopheresis (ECP) in adult patients with hematological malignancies early after RIC allo-HSCT on day ...
Lire la suite >We performed a prospective multicenter phase 2 study to evaluate the safety and efficacy of prophylactic Extracorporeal Photopheresis (ECP) in adult patients with hematological malignancies early after RIC allo-HSCT on day 21 twice per week during the first two weeks and then once per week for the next four weeks for a total of eight ECP courses. A total of 20 patients were included; 10 were males, median age was 60 years. All patients engrafted, 17 (85%) received the total eight ECP courses. There were no adverse effects related to ECP. Seven patients developed acute graft-versus-host disease (GVHD), with 15% grade ≥ II cumulative incidence at day 100. The cumulative incidence of chronic GVHD at 2 years was 22%. The 2 years probability of overall survival (OS) and progression-free survival (PFS) were 84 and 74%, respectively. This study shows encouraging results with low acute and chronic GVHD incidence and no interference with graft-versus-leukemia (GVL) effect.Lire moins >
Lire la suite >We performed a prospective multicenter phase 2 study to evaluate the safety and efficacy of prophylactic Extracorporeal Photopheresis (ECP) in adult patients with hematological malignancies early after RIC allo-HSCT on day 21 twice per week during the first two weeks and then once per week for the next four weeks for a total of eight ECP courses. A total of 20 patients were included; 10 were males, median age was 60 years. All patients engrafted, 17 (85%) received the total eight ECP courses. There were no adverse effects related to ECP. Seven patients developed acute graft-versus-host disease (GVHD), with 15% grade ≥ II cumulative incidence at day 100. The cumulative incidence of chronic GVHD at 2 years was 22%. The 2 years probability of overall survival (OS) and progression-free survival (PFS) were 84 and 74%, respectively. This study shows encouraging results with low acute and chronic GVHD incidence and no interference with graft-versus-leukemia (GVL) effect.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Équipe(s) de recherche :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Date de dépôt :
2019-03-01T15:24:18Z
2023-11-30T09:46:36Z
2023-11-30T09:46:36Z