Titre :

Disability, fatigue, pain and their associates in early diffuse cutaneous systemic sclerosis: the European Scleroderma Observational Study

Auteur(s) :

Peytrignet, Sebastien [Auteur]
Denton Christopher, P [Auteur]
Lunt, Mark [Auteur]
Hesselstrand, Roger [Auteur]
Mouthon, Luc [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Silman, Alan [Auteur]
Pan, Xiaoyan [Auteur]
Brown, Edith [Auteur]
Czirjak, Laszlo [Auteur]
Distler, Jorg [Auteur]
Distler, Oliver [Auteur]
Fligelstone, Kim [Auteur]
Gregory William, J [Auteur]
Ochiel, Rachel [Auteur]
Vonk, Madelon [Auteur]
Ancuta, Codrina [Auteur]
Ong Voon, H [Auteur]
Farge, Dominique [Auteur]
Hudson, Marie [Auteur]
Matucci-Cerinic, Marco [Auteur]
Balbir-Gurman, Alexandra [Auteur]
Midtvedt, Oyvind [Auteur]
Jordan Alison, C [Auteur]
Stevens, Wendy [Auteur]
Moinzadeh, Pia [Auteur]
Hall Frances, C [Auteur]
Agard, Christian [Auteur]
Université de Nantes [UN]
Anderson Marina, E [Auteur]
Diot, Elisabeth [Auteur]
Madhok, Rajan [Auteur]
Akil, Mohammed [Auteur]
Buch Maya, H [Auteur]
Chung, Lorinda [Auteur]
Damjanov, Nemanja [Auteur]
Gunawardena, Harsha [Auteur]
Lanyon, Peter [Auteur]
Ahmad, Yasmeen [Auteur]
Chakravarty, Kuntal [Auteur]
Jacobsen, Soren [Auteur]
Macgregor Alexander, J [Auteur]
Mchugh, Neil [Auteur]
Muller-Ladner, Ulf [Auteur]
Riemekasten, Gabriela [Auteur]
Becker, Michael [Auteur]
Roddy, Janet [Auteur]
Carreira Patricia, E [Auteur]
Fauchais, Anne-Laure [Auteur]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Hamilton, Jennifer [Auteur]
Inanc, Murat [Auteur]
Mclaren John, S [Auteur]
Van Laar Jacob, M [Auteur]
Pathare, Sanjay [Auteur]
Proudman, Susanna [Auteur]
Rudin, Anna [Auteur]
Sahhar, Joanne [Auteur]
Coppere, Brigitte [Auteur]
Serratrice, Christine [Auteur]
Sheeran, Tom [Auteur]
Veale Douglas, J [Auteur]
Grange, Claire [Auteur]
Trad, Georges-Selim [Auteur]
Herrick Ariane, L [Auteur]

Titre de la revue :

Rheumatology (Oxford, England)

Nom court de la revue :

RHEUMATOLOGY

Numéro :

57

Pagination :

370-381

Date de publication :

2018-02-01

ISSN :

1462-0324

Mot(s)-clé(s) :

disability
pain
hand function
fatigue
early diffuse cutaneous systemic sclerosis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Objectives: Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features. Methods: Patients ...
Lire la suite >Objectives: Our aim was to describe the burden of early dcSSc in terms of disability, fatigue and pain in the European Scleroderma Observational Study cohort, and to explore associated clinical features. Methods: Patients completed questionnaires at study entry, 12 and 24 months, including the HAQ disability index (HAQ-DI), the Cochin Hand Function Scale (CHFS), the Functional Assessment of Chronic Illness Therapy-fatigue and the Short Form 36 (SF36). Associates examined included the modified Rodnan skin score (mRSS), current digital ulcers and internal organ involvement. Correlations between 12-month changes were also examined. Results: The 326 patients recruited (median disease duration 11.9 months) displayed high levels of disability [mean (s.d.) HAQ-DI 1.1 (0.83)], with ‘grip’ and ‘activity’ being most affected. Of the 18 activities assessed in the CHFS, those involving fine finger movements were most affected. High HAQ-DI and CHFS scores were both associated with high mRSS (ρ = 0.34, P < 0.0001 and ρ = 0.35, P < 0.0001, respectively). HAQ-DI was higher in patients with digital ulcers (P = 0.004), pulmonary fibrosis (P = 0.005), cardiac (P = 0.005) and muscle involvement (P = 0.002). As anticipated, HAQ-DI, CHFS, the Functional Assessment of Chronic Illness Therapy and SF36 scores were all highly correlated, in particular the HAQ-DI with the CHFS (ρ = 0.84, P < 0.0001). Worsening HAQ-DI over 12 months was strongly associated with increasing mRSS (ρ = 0.40, P < 0.0001), decreasing hand function (ρ = 0.57, P < 0.0001) and increasing fatigue (ρ = −0.53, P < 0.0001). Conclusion: The European Scleroderma Observational Study highlights the burden of disability in early dcSSc, with high levels of disability and fatigue, associating with the degree of skin thickening (mRSS). Impaired hand function is a major contributor to overall disability.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

Inserm
Université de Lille
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Équipe(s) de recherche :

Immunity, inflammation and fibrsis in auto and allo-reactivity

Date de dépôt :

2019-03-01T15:24:43Z
2023-12-01T14:14:45Z