Heteropolysaccharides from S. cerevisiae ...
Document type :
Article dans une revue scientifique: Article de synthèse/Review paper
Permalink :
Title :
Heteropolysaccharides from S. cerevisiae show anti-adhesive properties against E. coli associated with Crohn’s disease
Author(s) :
Sivignon, Adeline [Auteur]
Yu, Shin-Yi [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Ballet, Nathalie [Auteur]
Vandekerckove, Pascal [Auteur]
Barnich, Nicolas [Auteur]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Yu, Shin-Yi [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Ballet, Nathalie [Auteur]
Vandekerckove, Pascal [Auteur]
Barnich, Nicolas [Auteur]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Journal title :
Carbohydrate Polymers
Abbreviated title :
Carbohydrate Polymers
Volume number :
271
Pages :
118415
Publisher :
Elsevier BV
Publication date :
2021-07-08
ISSN :
0144-8617
English keyword(s) :
Mannan-glucan heteropolysaccharides
Adherent-invasive Escherichia coli
Saccharomyces cerevisiae
Anti-adhesive strategy
NMR analysis
Adherent-invasive Escherichia coli
Saccharomyces cerevisiae
Anti-adhesive strategy
NMR analysis
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
The Saccharomyces cerevisiae CNCM I-3856 was previously reported to strongly inhibit adherent-invasive Escherichia coli (AIEC) adhesion to intestinal epithelial cells in vitro and to favor AIEC elimination from the gut in ...
Show more >The Saccharomyces cerevisiae CNCM I-3856 was previously reported to strongly inhibit adherent-invasive Escherichia coli (AIEC) adhesion to intestinal epithelial cells in vitro and to favor AIEC elimination from the gut in a murine model of Crohn's disease in vivo. In order to identify which cell wall components of yeast are responsible for AIEC elimination, constituent polysaccharides of yeast were isolated and their anti-adhesive ability against AIEC adhesion in vitro was screened. A fraction containing mannan, β-glucan and α-glucan extracted from yeast cell-walls was shown to inhibit 95% of AIEC adhesion in vitro and was thus identified as the strongest anti-adhesive yeast cell wall component. Furthermore, this mannan-glucan-containing fraction was shown to accelerate AIEC decolonization from gut in vivo. This fraction could be proposed as a treatment to eliminate AIEC bacteria in patients with Crohn's disease, a microbial trigger of intestinal inflammation.Show less >
Show more >The Saccharomyces cerevisiae CNCM I-3856 was previously reported to strongly inhibit adherent-invasive Escherichia coli (AIEC) adhesion to intestinal epithelial cells in vitro and to favor AIEC elimination from the gut in a murine model of Crohn's disease in vivo. In order to identify which cell wall components of yeast are responsible for AIEC elimination, constituent polysaccharides of yeast were isolated and their anti-adhesive ability against AIEC adhesion in vitro was screened. A fraction containing mannan, β-glucan and α-glucan extracted from yeast cell-walls was shown to inhibit 95% of AIEC adhesion in vitro and was thus identified as the strongest anti-adhesive yeast cell wall component. Furthermore, this mannan-glucan-containing fraction was shown to accelerate AIEC decolonization from gut in vivo. This fraction could be proposed as a treatment to eliminate AIEC bacteria in patients with Crohn's disease, a microbial trigger of intestinal inflammation.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
Université de Lille
CNRS
CNRS
Research team(s) :
Chemical Glycobiology
Submission date :
2021-10-08T09:48:18Z
2021-10-11T12:39:56Z
2021-10-12T08:14:29Z
2021-10-11T12:39:56Z
2021-10-12T08:14:29Z
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