Structural insight into the role of the ...
Document type :
Compte-rendu et recension critique d'ouvrage
Title :
Structural insight into the role of the PAS domain for signal transduction in sensor-kinase BvgS
Author(s) :
Dupré, Elian [Auteur]
Clantin, Bernard [Auteur]
Yuan, Youhua [Auteur]
Lecher, Sophie [Auteur]
Lesne, Elodie [Auteur]
Antoine, Rudy [Auteur]
Villeret, Vincent [Auteur]
Jacob, Francoise [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Clantin, Bernard [Auteur]
Yuan, Youhua [Auteur]
Lecher, Sophie [Auteur]
Lesne, Elodie [Auteur]
Antoine, Rudy [Auteur]
Villeret, Vincent [Auteur]
Jacob, Francoise [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Journal title :
Journal of Bacteriology
Publisher :
American Society for Microbiology
Publication date :
2021-05
ISSN :
0021-9193
English keyword(s) :
PAS domain of BvgS Two-component system
Bordetella pertussis
sensor-kinases
PAS domain
virulence regulation
Bordetella pertussis
sensor-kinases
PAS domain
virulence regulation
HAL domain(s) :
Sciences du Vivant [q-bio]/Microbiologie et Parasitologie/Bactériologie
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie structurale [q-bio.BM]
Sciences du Vivant [q-bio]/Biochimie, Biologie Moléculaire/Biologie structurale [q-bio.BM]
English abstract : [en]
The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus flytrap (VFT) domains. The VFT domains are ...
Show more >The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus flytrap (VFT) domains. The VFT domains are connected to the cytoplasmic kinase moiety by helical linkers separated by a Per-ARNT-Sim (PAS) domain. Antagonism between the two linkers, as one forms a coiled coil when the other is dynamic and vice versa, regulates BvgS activity. Here we solved the structure of the intervening PAS domain by X-rayShow less >
Show more >The two-component system BvgAS controls the virulence regulon in Bordetella pertussis. BvgS is the prototype of a family of sensor histidine-kinases harboring periplasmic Venus flytrap (VFT) domains. The VFT domains are connected to the cytoplasmic kinase moiety by helical linkers separated by a Per-ARNT-Sim (PAS) domain. Antagonism between the two linkers, as one forms a coiled coil when the other is dynamic and vice versa, regulates BvgS activity. Here we solved the structure of the intervening PAS domain by X-rayShow less >
Language :
Anglais
Popular science :
Non
Source :
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