Titre :

Influenza A Virus Infection Induces White Adipose Tissue Browning: A Metabolic Adaptation to Infection?

Auteur(s) :

Barthelemy, Johanna [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Wolowczuk, Isabelle [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Titre de la revue :

Journal of Cellular Immunology

Pagination :

276-283

Éditeur :

Scientific Archives

Date de publication :

2020

ISSN :

2689-2812

Mot(s)-clé(s) en anglais :

Adipose tissue
Browning
Influenza A virus

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Anatomie, Histologie, Anatomopathologie [q-bio.TO]

Résumé en anglais : [en]

We recently reported that influenza infection is associated with drastic, depot-specific changes in white adipose tissue (WAT), notably the occurrence of thermogenic brown-like adipocytes within the subcutaneous depot, a ...
Lire la suite >We recently reported that influenza infection is associated with drastic, depot-specific changes in white adipose tissue (WAT), notably the occurrence of thermogenic brown-like adipocytes within the subcutaneous depot, a process referred to as WAT browning. In mammals, induction of the thermogenic circuit increases heat production and consumes energy, consequently improving host’s metabolism. Importantly, we also demonstrated that mouse and human preadipocytes commit to the thermogenic differentiation program upon in vitro influenza virus infection; this signifies that infection-associated WAT browning may partly rely on a direct effect of the virus on fat.Herein, after a short review of the physiological and cellular mechanisms that have been described to regulate WAT browning, including immune-cell-dependent ones, we will comment on the role that white adipose tissue, which is at the crossroads of metabolism and immunity, may play in influenza pathophysiology.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017

Source :

Harvested from HAL