Title :

BONE PERFUSION AND ADIPOSITY BEYOND THE NECROTIC ZONE IN FEMORAL HEAD OSTEONECROSIS: A QUANTITATIVE MRI STUDY

Author(s) :

Cultot, Aurélie [Auteur]
Université catholique de Lille [UCL]
Norberciak, Laurène [Auteur]
Université catholique de Lille [UCL]
Coursier, Raphaël [Auteur]
Hôpital Saint Philibert [Lomme]
Hôpital Saint Vincent de Paul de Lille
Putman, Sophie [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
Cortet, Bernard [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Physiopathologie des Maladies Osseuses Inflammatoires (PMOI) - ULR 4490
Paccou, Julien [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Physiopathologie des Maladies Osseuses Inflammatoires (PMOI) - ULR 4490
Pascart, Tristan [Auteur]
Marrow Adiposity & Bone Lab (MABLab) - ULR 4490
Budzik, Jean-Francois [Auteur]
Université catholique de Lille [UCL]

Journal title :

European Journal of Radiology

Abbreviated title :

European Journal of Radiology

Volume number :

131

Pages :

109206

Publisher :

Elsevier

Publication date :

2020-10

ISSN :

0720048X

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Purpose To describe bone perfusion and adiposity beyond the necrotic zone with quantitative MRI techniques in osteonecrosis of the femoral head (ONFH). Method In this cross-sectional multicentre study, we recruited ...
Show more >Purpose To describe bone perfusion and adiposity beyond the necrotic zone with quantitative MRI techniques in osteonecrosis of the femoral head (ONFH). Method In this cross-sectional multicentre study, we recruited patients suffering from late-stage ONFH or hip osteoarthritis. Hip MRI included quantitative MRI sequences: chemical-shift imaging and dynamic contrast-enhanced MRI. We drew regions of interest inside the necrotic zone (inner necrosis and its border) and outside (femoral head, neck and greater trochanter) in ONFH. In the control group, regions of interest were drawn in the femoral head, femoral neck and the greater trochanter. For each region of interest, we measured fat fraction, and calculated semi-quantitative (area under the curve, initial slope) and pharmacokinetic perfusion parameters (Ktrans and Kep). Results Thirty-two male adults (mean age 58 ± 9 years, range 38–74 years) were included. Sixteen patients formed the ONFH group and fifteen the control group; one was excluded. In the normal-appearing non-necrotic part of the femoral head, fat fraction was not significantly different in comparison with controls (p = 1), but Ktrans was significantly lower than in controls (0.012 ± 0.018 vs. 0.027 ± 0.045; p = 0.05). This perfusion parameter reflects exchanges between blood microvessels and bone marrow. Conclusions Our results question the concept of adipose toxicity on the macroscopic scale, and bring up the concept of regional ischemic penumbra that goes beyond the visible necrotic zone. Further studies are required to test these hypotheses in larger populations and earlier disease states.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Univ. Littoral Côte d’Opale
Université de Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2021-12-08T09:51:47Z
2024-03-20T10:41:44Z