Title :

Synthesis and biological studies of "Polycerasoidol" and "trans-δ-Tocotrienolic acid" derivatives as PPARα and/or PPARγ agonists

Author(s) :

Vila, Laura [Auteur]
Universitat de València = University of Valencia [UV]
Cabedo, Nuria [Auteur]
Universitat de València = University of Valencia [UV]
Villarroel-Vicente, Carlos [Auteur]
Universitat de València = University of Valencia [UV]
García, Ainhoa [Auteur]
Universitat de València = University of Valencia [UV]
Bernabeu, Álvaro [Auteur]
Universitat de València = University of Valencia [UV]
Hennuyer, Nathalie [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Staels, Bart [Auteur]
Récepteurs Nucléaires, Maladies Métaboliques et Cardiovasculaires - U 1011 [RNMCD]
Franck, Xavier [Auteur]
Chimie Organique et Bioorganique : Réactivité et Analyse [COBRA]
Figadère, Bruno [Auteur]
Biomolécules : Conception, Isolement, Synthèse [BioCIS]
Sanz, María-Jesús [Auteur]
Universitat de València = University of Valencia [UV]
Cortes, Diego [Auteur]
Universitat de València = University of Valencia [UV]

Journal title :

Bioorganic and Medicinal Chemistry

Pages :

116532

Publisher :

Elsevier

Publication date :

2022

ISSN :

0968-0896

English keyword(s) :

2-Prenylated benzopyrans
polycerasoidol analogs
tocotrienol analogs
Grignard/Johnson-Claisen rearrangement
Wittig olefination
hPPAR activity

HAL domain(s) :

Chimie/Chimie thérapeutique
Chimie/Chimie organique

English abstract : [en]

2-Prenylated benzopyrans represent a class of natural and synthetic compounds showing a wide range of significant activities. Polycerasoidol is a natural prenylated benzopyran isolated from the stem bark of Polyalthia ...
Show more >2-Prenylated benzopyrans represent a class of natural and synthetic compounds showing a wide range of significant activities. Polycerasoidol is a natural prenylated benzopyran isolated from the stem bark of Polyalthia cerasoides (Annonaceae) that exhibits dual PPARα/γ agonism and an anti-inflammatory effect by inhibiting mononuclear leukocyte adhesion to the dysfunctional endothelium. Herein, we report the synthesis of three new series of prenylated benzopyrans containing one (series 1), two (series 2, "polycerasoidol" analogs) and three (series 3, "trans-δ-tocotrienolic acid" analogs) isoprenoid units in the hydrocarbon side chain at the 2-position of the chroman-6-ol (6hydroxy-dihydrobenzopyran) scaffold. Isoprenoid moieties were introduced through a Grignard reaction sequence, followed by Johnson-Claisen rearrangement and subsequent Wittig olefination. hPPAR transactivation activity and the structure activity relationships (SAR) of eleven novel synthesized 2-prenylated benzopyrans were explored. PPAR transactivation activity demonstrated that the seven-carbon side chain analogs (series 1) displayed selectivity for hPPARα, while the nine-carbon side chain analogs (polycerasoidol analogs, series 2) did so for hPPARγ. The side chain elongation to 11 or 13 carbons (series 3) resulted in weak dual PPARα/γ activation. Therefore, 2-prenylated benzopyrans of sevenand nine-carbon side chain (polycerasoidol analogs) are good lead compounds for developing useful candidates to prevent cardiovascular diseases associated with metabolic disorders.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

ANR Project :

EGID Diabetes Pole

Collections :

• Récepteurs nucléaires, Maladies Cardiovasculaires et Diabète (RNMCD) - U1011

Source :

Harvested from HAL