Toxoplasma and Dendritic Cells

Poncet, Anaïs F.; Blanchard, Nicolas; Marion, Sabrina

An Intimate Relationship That Deserves Further Scrutiny

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1016/j.pt.2019.08.001

PMID :

31492624

Titre :

Toxoplasma and Dendritic Cells
An Intimate Relationship That Deserves Further Scrutiny

Auteur(s) :

Poncet, Anaïs F. [Auteur]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Blanchard, Nicolas [Auteur correspondant]
Centre de Physiopathologie Toulouse Purpan [CPTP]
Marion, Sabrina [Auteur correspondant]
Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]

Titre de la revue :

Trends in parasitology

Pagination :

870 - 886

Éditeur :

Elsevier

Date de publication :

2019-11-30

ISSN :

1471-4922

Mot(s)-clé(s) en anglais :

Toxoplasma gondii
antigen presentation
dendritic cells
innate sensing
migration

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to ...
Lire la suite >Toxoplasma gondii (Tg), an obligate intracellular parasite of the phylum Apicomplexa, infects a wide range of animals, including humans. A hallmark of Tg infection is the subversion of host responses, which is thought to favor parasite persistence and propagation to new hosts. Recently, a variety of parasite-secreted modulatory effectors have been uncovered in fibroblasts and macrophages, but the specific interplay between Tg and dendritic cells (DCs) is just beginning to emerge. In this review, we summarize the current knowledge on Tg-DC interactions, including innate recognition, cytokine production, and antigen presentation, and discuss open questions regarding how Tg-secreted effectors may shape DC functions to perturb innate and adaptive immunity.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :