Title :

Effects of Aluminium Contamination on the Nervous System of Freshwater Aquatic Vertebrates: A Review

Author(s) :

Closset, Marie [Auteur]
Cailliau, Katia [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Slaby, Sylvain [Auteur]
Stress Environnementaux et BIOsurveillance des milieux aquatiques [SEBIO]
Marin, Matthieu [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Journal title :

International journal of molecular sciences

Abbreviated title :

IJMS

Volume number :

23

Pages :

31

Publisher :

MDPI AG

Publication date :

2021-12-21

ISSN :

1422-0067

English keyword(s) :

aquatic contamination
aluminium
nervous system
development
Xenopus
zebrafish

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Aluminium (Al) is the most common natural metallic element in the Earth’s crust. It is released into the environment through natural processes and human activities and accumulates in aquatic environments. This review ...
Show more >Aluminium (Al) is the most common natural metallic element in the Earth’s crust. It is released into the environment through natural processes and human activities and accumulates in aquatic environments. This review compiles scientific data on the neurotoxicity of aluminium contamination on the nervous system of aquatic organisms. More precisely, it helps identify biomarkers of aluminium exposure for aquatic environment biomonitoring in freshwater aquatic vertebrates. Al is neurotoxic and accumulates in the nervous system of aquatic vertebrates, which is why it could be responsible for oxidative stress. In addition, it activates and inhibits antioxidant enzymes and leads to changes in acetylcholinesterase activity, neurotransmitter levels, and in the expression of several neural genes and nerve cell components. It also causes histological changes in nerve tissue, modifications of organism behaviour, and cognitive deficit. However, impacts of aluminium exposure on the early stages of aquatic vertebrate development are poorly described. Lastly, this review also poses the question of how accurate aquatic vertebrates (fishes and amphibians) could be used as model organisms to complement biological data relating to the developmental aspect. This “challenge” is very relevant since freshwater pollution with heavy metals has increased in the last few decades.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Régulation des signaux de division

Submission date :

2022-01-19T15:23:10Z
2022-01-20T13:15:58Z