Water content thresholds in glycerol/water system: Low- and high-wavenumber Raman spectroscopy study

Starciuc, Tatiana; Guinet, Yannick; Hédoux, Alain; Shalaev, Evgenyi

Type de document :

Article dans une revue scientifique: Article original

URL permanente :

http://hdl.handle.net/20.500.12210/59484

Titre :

Water content thresholds in glycerol/water system: Low- and high-wavenumber Raman spectroscopy study

Auteur(s) :

Starciuc, Tatiana [Auteur]
Guinet, Yannick [Auteur]
Hédoux, Alain [Auteur]
Shalaev, Evgenyi [Auteur]

Titre de la revue :

Journal of Molecular Liquids

Numéro :

321

Pagination :

114678

Date de publication :

2021

Résumé en anglais : [en]

Water structure is the key in such diverse processes as protein folding, catalysis of chemical reactions, and stability of pharmaceuticals and biopharmaceuticals. In the current investigation, glycerol-water mixtures are ...
Lire la suite >Water structure is the key in such diverse processes as protein folding, catalysis of chemical reactions, and stability of pharmaceuticals and biopharmaceuticals. In the current investigation, glycerol-water mixtures are studied by low- and high-wavenumber Raman spectroscopy. Three water content regions, which are separated by two water content thresholds (WT), WT1 at 6.1 ± 0.7 wt% water and WT2 at 18.6 ± 4.4 wt% water, are identified, based on the trends in the hydrogen bond strength and the cage effect. It is hypothesized that WT1 corresponds to a transition from predominantly unclustered water molecules to small water clusters, and is associated with facilitation of proton transfer as water content exceeds WT1. The WT2 is proposed to mark formation of large (>100 molecules) water clusters, which can form stable nucleus of hexagonal ice at lower temperatures. These findings, if confirmed for other polyhydroxycompounds, could facilitate development of novel pharmaceuticals and vaccines, and also contribute to fundamental understanding of mechanisms of cryo- and lyo-protection of proteins, viruses, and cells.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
CNRS
INRA
ENSCL

Collections :

Unité Matériaux et Transformations (UMET) - UMR 8207

Équipe(s) de recherche :

Matériaux Moléculaires et Thérapeutiques

Date de dépôt :

2022-01-28T09:16:49Z

Numéro de version	Lien	Date de modification
2	20.500.12210/59484	2022-02-01T10:55:33Z
1	20.500.12210/59484.1*	2022-01-28T09:16:49Z

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