Title :

Whole and fractionated human platelet lysate biomaterials-based biotherapy induces strong neuroprotection in experimental models of amyotrophic lateral sclerosis

Author(s) :

Gouel, Flore [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Timmerman, Kelly [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Gosset, Philippe [Auteur]
Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
Raoul, Cedric [Auteur]
Institut des Neurosciences de Montpellier [INM]
Dutheil, Mary [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Jonneaux, Aurelie [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Garcon, Guillaume [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
moreau, caroline [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172
Danel-Brunaud, Veronique [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Duce, James A. [Auteur]
University of Cambridge [UK] [CAM]
Burnouf, Thierry [Auteur]
Taipei Medical University
Devedjian, Jean-Christophe [Auteur]
Lille Neurosciences & Cognition - U 1172 [LilNCog]
DEVOS, DAVID [Auteur]
Lille Neurosciences & Cognition (LilNCog) - U 1172

Journal title :

Biomaterials

Abbreviated title :

Biomaterials

Volume number :

280

Pages :

121311

Publisher :

Elsevier

Publication date :

2021-12-04

ISSN :

1878-5905

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of motor neurons leading to death within 3 years and without a curative treatment. Neurotrophic growth factors (NTFs) are pivotal for cell ...
Show more >Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease of motor neurons leading to death within 3 years and without a curative treatment. Neurotrophic growth factors (NTFs) are pivotal for cell survival. A reason for the lack of patient efficacy with single recombinant NTF brain infusion is likely to be due to the synergistic neuroprotective action of multiple NTFs on a diverse set of signaling pathways. Fractionated (protein size <50, <30, <10, <3 kDa) heat-treated human platelet lysate (HHPL) preparations were adapted for use in brain tissue with the aim of demonstrating therapeutic value in ALS models and further elucidation of the mechanisms of action. In neuronal culture all fractions induced Akt-dependent neuroprotection as well as a strong anti-apoptotic and anti-ferroptotic action. In the <3 kDa fraction anti-ferroptotic properties were shown to be GPX4 dependent highlighting a role for other platelet elements associated with NTFs. In the SOD1G86RShow less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
CNRS
Inserm
Institut Pasteur de Lille
Université de Lille

Collections :

• Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 9017
• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
• Lille Neurosciences & Cognition (LilNCog) - U 1172

Research team(s) :

Troubles cognitifs dégénératifs et vasculaires

Submission date :

2022-02-02T10:23:14Z
2022-04-20T07:14:17Z