Comparison of in vitro endocrine activity of phthalates and alternative plasticizers

Moche, Helene; Chentouf, Aouatif; Neves, Sergio; Corpart, Jean-Marc; Nesslany, Fabrice

Type de document :

Article dans une revue scientifique: Article original

DOI :

10.1155/2021/8815202

PMID :

33628236

URL permanente :

http://hdl.handle.net/20.500.12210/59627

Titre :

Comparison of in vitro endocrine activity of phthalates and alternative plasticizers

Auteur(s) :

Moche, Helene [Auteur]
Institut Pasteur de Lille
Chentouf, Aouatif [Auteur]
Neves, Sergio [Auteur]
Corpart, Jean-Marc [Auteur]
Nesslany, Fabrice [Auteur]

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Titre de la revue :

Journal of toxicology

Nom court de la revue :

J Toxicol

Numéro :

2021

Pagination :

8815202

Date de publication :

2021-01-01

ISSN :

1687-8191

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Because of the deleterious effects of phthalates, regulations have been taken to decrease their use, and the needs for alternatives are increasing. Due to the concerns about the endocrine-disrupting properties of phthalates, ...
Lire la suite >Because of the deleterious effects of phthalates, regulations have been taken to decrease their use, and the needs for alternatives are increasing. Due to the concerns about the endocrine-disrupting properties of phthalates, it was deemed necessary to particularly investigate these effects for potential substitutes. In this study, we compared the in vitro endocrine activity of several already used potential alternative plasticizers (DEHT, DINCH, and TOTM) or new substitutes (POLYSORB® isosorbide and POLYSORB® ID 46) to one of 2 phthalates, DEHP and DINP. Effects of these chemicals on 3 common mechanisms of endocrine disruption, i.e., interaction with estrogen receptors (ER), androgen receptors (AR), or steroidogenesis, were studied using extensively used in vitro methods. In the E-Screen assay, only DEHP moderately induced MCF-7 cell proliferation; none of the other tested substances were estrogenic or antiestrogenic. No androgenic or antiandrogenic activity in MDA-kb2 cells was shown for any of the tested phthalates or alternatives. On the other hand, both DEHP and DINP, as well as DEHT, DINCH, and TOTM, disrupted steroidogenesis in the H295R assay, mainly by inducing an increase in estradiol synthesis; no such effect was observed for POLYSORB® isosorbide and POLYSORB® ID 46.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Date de dépôt :

2022-02-02T10:23:15Z
2022-08-24T09:24:28Z

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Ce document est diffusé sous licence Attribution 3.0 United States

Numéro de version	Lien	Date de modification
2	20.500.12210/59627*	2022-08-24T09:20:34Z
1	20.500.12210/59627.1	2022-02-02T10:23:15Z

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