Title :

Phase 1 dose escalation trial of ipilimumab and stereotactic body radiation therapy in metastatic melanoma

Author(s) :

Sundahl, Nora [Auteur]
Ghent University Hospital
De Wolf, Katrien [Auteur]
Ghent University Hospital
Kruse, Vibeke [Auteur]
Ghent University Hospital
Meireson, Annabel [Auteur]
Ghent University Hospital
Reynders, Dries [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Goetghebeur, Els [Auteur]
Universiteit Gent = Ghent University = Université de Gand [UGENT]
Van Gele, Mireille [Auteur]
Ghent University Hospital
Speeckaert, Reinhart [Auteur]
Ghent University Hospital
Hennart, Benjamin [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Brochez, Lieve [Auteur]
Ghent University Hospital
Ost, Piet [Auteur]
Ghent University Hospital

Journal title :

International journal of radiation oncology, biology, physics

Abbreviated title :

Int. J. Radiat. Oncol. Biol. Phys.

Volume number :

100

Pages :

906-915

Publisher :

Elsevier

Publication date :

2018-03-15

ISSN :

0360-3016

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

To report the results of a phase 1 trial evaluating the safety of the ipilimumab/radiation therapy combination in patients with metastatic melanoma. Thirteen patients with metastatic melanoma were enrolled. Trial treatment ...
Show more >To report the results of a phase 1 trial evaluating the safety of the ipilimumab/radiation therapy combination in patients with metastatic melanoma. Thirteen patients with metastatic melanoma were enrolled. Trial treatment consisted of 4 cycles of ipilimumab in combination with concurrent dose-escalated high-dose radiation therapy to 1 lesion administered before the third cycle of ipilimumab. Grade 3 or 4 ipilimumab-related adverse events occurred in 25% of patients. The maximum tolerated radiation therapy dose was not reached. Local control of the irradiated lesions was achieved in 11 of 12 irradiated patients (1 patient had progressive disease before irradiation and dropped out of the trial). Evaluation of the nonirradiated lesions demonstrated that 3 of 13 patients experienced clinical benefit, with 1 patient developing a partial response and 2 patients having confirmed stable disease. Immunomonitoring data showed that in patients without clinical benefit, factors linked to immunotolerance increased early after the initiation of ipilimumab, suggesting that early initiation of radiation therapy might be more effective if combined with ipilimumab. Our findings suggest that the combination of ipilimumab and high-dose radiation therapy is feasible and safe.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CHU Lille
Institut Pasteur de Lille
Université de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2022-02-02T10:23:18Z
2024-03-13T09:38:40Z