Title :

Visible-light-driven carboxylic amine protocol (clap) for the synthesis of 2-substituted piperazines under batch and flow conditions

Author(s) :

Gueret, Robin [Auteur]
Unité de Catalyse et Chimie du Solide - UMR 8181 [UCCS]
Pelinski, Lydie [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Bousquet, Till [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Sauthier, Mathieu [Auteur]
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Ferey, Vincent [Auteur]
SANOFI Recherche
Bigot, Antony [Auteur]
Sanofi [Vitry-sur-Seine]

Journal title :

Organic Letters

Abbreviated title :

Org. Lett.

Volume number :

22

Pages :

5157–5162

Publisher :

American Chemical Society (ACS)

Publication date :

2020-06-23

ISSN :

1523-7052

English keyword(s) :

Aldehydes
Amines
Chemical reactions
Irradiation
Photocatalysts

HAL domain(s) :

Chimie/Catalyse

English abstract : [en]

Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, ...
Show more >Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl piperazines. The iridium-based complex [Ir(ppy)2(dtbpy)]PF6 and carbazolyl dicyanobenzene 4CzIPN were found to be the photocatalysts of choice to efficiently perform the transformation under mild conditions, whether in batch or in continuous mode.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Other project(s) or funding source(s) :

Sanofi
CNRS
Chevreul Institute (FR 2638)
Ministère de l’Enseignement Supérieur et de la Recherche
Région Nord Pas-de-Calais
FEDER

Administrative institution(s) :

CNRS
Centrale Lille
ENSCL
Univ. Artois
Université de Lille

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Research team(s) :

Catalyse et synthèse éco-compatible (CASECO)

Submission date :

2022-03-02T07:13:36Z
2023-11-28T15:47:25Z