Immobilized lipase screening towards ...
Type de document :
Article dans une revue scientifique: Article original
URL permanente :
Titre :
Immobilized lipase screening towards continuous-flow kinetic resolution of (+/-)-1,2-propanediol
Auteur(s) :
Aguillon, Anderson R. [Auteur]
Avelar, Marcelo N. [Auteur]
Gotardo, Larissa E. [Auteur]
De Souza, Stefania P. [Auteur]
Leao, Raquel A. C. [Auteur]
Itabaiana, Ivaldo [Auteur]
Miranda, Leandro S. M. [Auteur]
De Souza, Rodrigo Octavio Mendonca Alves [Auteur]
Avelar, Marcelo N. [Auteur]
Gotardo, Larissa E. [Auteur]
De Souza, Stefania P. [Auteur]
Leao, Raquel A. C. [Auteur]
Itabaiana, Ivaldo [Auteur]
Miranda, Leandro S. M. [Auteur]
De Souza, Rodrigo Octavio Mendonca Alves [Auteur]
Titre de la revue :
Molecular Catalysis
Nom court de la revue :
Mol. Catal.
Numéro :
467
Pagination :
128-134
Date de publication :
2019-04-01
ISSN :
2468-8231
Mot(s)-clé(s) en anglais :
Kinetic resolution
Lipase
Continuous-flow
Lipase
Continuous-flow
Discipline(s) HAL :
Chimie/Catalyse
Résumé en anglais : [en]
Here, we report a flow chemistry approach for kinetic resolution of (±)-1,2-propanediol protected by trityl group using the packed-bed reactor filled with different immobilized enzymes. It was investigated the performance ...
Lire la suite >Here, we report a flow chemistry approach for kinetic resolution of (±)-1,2-propanediol protected by trityl group using the packed-bed reactor filled with different immobilized enzymes. It was investigated the performance of 16 immobilized lipases, including commercial Lipozyme TL, Novozym 51032, Novozym 435 (N435) and lipases immobilized by our group. Based on the values of conversion and enantioseletivity, batch experiments were then translated to the continuous-flow environment. Continuous flow (CF) reactors allowed reaction time reduction, from 6 h in batch to 7 min, keeping the values of conversion (up to 50%) and selectivity (E value >200) during the reaction procedure using the commercial enzyme Novozym 435. In addition, continuous flow conditions increased the productivity of kinetic resolution 3 times when compared to conventional batch reactor, after its optimization.Lire moins >
Lire la suite >Here, we report a flow chemistry approach for kinetic resolution of (±)-1,2-propanediol protected by trityl group using the packed-bed reactor filled with different immobilized enzymes. It was investigated the performance of 16 immobilized lipases, including commercial Lipozyme TL, Novozym 51032, Novozym 435 (N435) and lipases immobilized by our group. Based on the values of conversion and enantioseletivity, batch experiments were then translated to the continuous-flow environment. Continuous flow (CF) reactors allowed reaction time reduction, from 6 h in batch to 7 min, keeping the values of conversion (up to 50%) and selectivity (E value >200) during the reaction procedure using the commercial enzyme Novozym 435. In addition, continuous flow conditions increased the productivity of kinetic resolution 3 times when compared to conventional batch reactor, after its optimization.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
CNRS
Centrale Lille
ENSCL
Univ. Artois
Université de Lille
Centrale Lille
ENSCL
Univ. Artois
Université de Lille
Collections :
Date de dépôt :
2022-03-02T07:13:47Z