Title :

New lipidyl-cyclodextrins obtained by ring opening of methyl oleate epoxide using ball milling

Author(s) :

Oliva, Estefania [Auteur]
Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 [LG2A ]
Mathiron, David [Auteur]
Université de Picardie Jules Verne [UPJV]
Rigaud, Sebastien [Auteur]
Université de Picardie Jules Verne [UPJV]
Monflier, Eric [Auteur]
UCCS Équipe Catalyse Supramoléculaire
Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181
Sevin, Emmanuel [Auteur]
Laboratoire de Physiopathologie de la Barrière Hémato-Encéphalique [LBHE]
Bricout, Herve [Auteur]
UCCS Équipe Catalyse Supramoléculaire
Tilloy, Sebastien [Auteur]
UCCS Équipe Catalyse Supramoléculaire
Gosselet, Fabien [Auteur]
Laboratoire de la Barrière Hémato-Encéphalique [LBHE]
Fenart, Laurence [Auteur]
Laboratoire de Physiopathologie de la Barrière Hémato-Encéphalique [LBHE]
Bonnet, Veronique [Auteur]
Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 [LG2A ]
Pilard, Serge [Auteur]
Université de Picardie Jules Verne [UPJV]
Djedaini-Pilard, Florence [Auteur]
Laboratoire de Glycochimie, des Antimicrobiens et des Agro-ressources - UMR CNRS 7378 [LG2A ]

Journal title :

Biomolecules

Abbreviated title :

Biomolecules

Volume number :

10

Pages :

339

Publication date :

2020-02-20

ISSN :

2218-273X

Keyword(s) :

sustainability
host-guest chemistry
ball milling
cyclodextrin
mass spectrometry

HAL domain(s) :

Chimie/Catalyse

English abstract : [en]

Bearing grafts based on fatty esters derivatives, lipidyl-cyclodextrins (L-CDs) are compounds able to form water-soluble nano-objects. In this context, bicatenary biobased lipidic-cyclodextrins of low DS were easily ...
Show more >Bearing grafts based on fatty esters derivatives, lipidyl-cyclodextrins (L-CDs) are compounds able to form water-soluble nano-objects. In this context, bicatenary biobased lipidic-cyclodextrins of low DS were easily synthesized from a fatty ester epoxide by means of alternative methods (ball-milling conditions, use of enzymes). The ring opening reaction of methyl oleate epoxide needs ball-milling and is highly specific of cyclodextrins in solventless conditions. L-CDs are thus composed of complex mixtures that were deciphered by an extensive structural analysis using mainly mass spectrometry and NMR spectroscopy. In addition, as part of their potential use as vectors of active drugs, these products were submitted to an integrity study on in vitro model of the blood-brain-barrier (BBB) and the intestinal epithelium. No toxicity has been observed, suggesting that applications for the vectorization of active ingredients can be expected.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

CNRS
Centrale Lille
ENSCL
Univ. Artois
Université de Lille

Collections :

• Unité de Catalyse et Chimie du Solide (UCCS) - UMR 8181

Research team(s) :

Catalyse et chimie supramoléculaire (CASU)

Submission date :

2022-03-02T07:14:30Z
2023-01-25T11:39:38Z