Titre :

Clinical translation of advanced colonic drug delivery technologies

Auteur(s) :

Awad, Atheer [Auteur]
University College of London [London] [UCL]
Madla, Christine M. [Auteur]
University College of London [London] [UCL]
Mccoubrey, Laura E. [Auteur]
University College of London [London] [UCL]
Ferraro, Fabiana [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Gavins, Francesca K. H. [Auteur]
University College of London [London] [UCL]
Buanz, Asma [Auteur]
University College of London [London] [UCL]
Gaisford, Simon [Auteur]
University College of London [London] [UCL]
Orlu, Mine [Auteur]
University College of London [London] [UCL]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Basit, Abdul W. [Auteur]
University College of London [London] [UCL]

Titre de la revue :

Advanced Drug Delivery Reviews

Nom court de la revue :

Adv Drug Deliv Rev

Numéro :

181

Pagination :

114076

Date de publication :

2021-12-07

ISSN :

1872-8294

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. ...
Lire la suite >Targeted drug delivery to the colon offers a myriad of benefits, including treatment of local diseases, direct access to unique therapeutic targets and the potential for increasing systemic drug bioavailability and efficacy. Although a range of traditional colonic delivery technologies are available, these systems exhibit inconsistent drug release due to physiological variability between and within individuals, which may be further exacerbated by underlying disease states. In recent years, significant translational and commercial advances have been made with the introduction of new technologies that incorporate independent multi-stimuli release mechanisms (pH and/or microbiota-dependent release). Harnessing these advanced technologies offers new possibilities for drug delivery via the colon, including the delivery of biopharmaceuticals, vaccines, nutrients, and microbiome therapeutics for the treatment of both local and systemic diseases. This review details the latest advances in colonic drug delivery, with an emphasis on emerging therapeutic opportunities and clinical technology translation.Lire moins >

Langue :

Anglais

Audience :

Internationale

Vulgarisation :

Non

Établissement(s) :

CHU Lille
Inserm
Université de Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Équipe(s) de recherche :

U1008

Date de dépôt :

2022-04-13T07:12:05Z
2024-02-16T13:53:53Z