Titre :

Prognostic factors of BRAF V600E colorectal cancer with liver metastases: a retrospective multicentric study

Auteur(s) :

Javed, Sahir [Auteur]
Centre Régional de Lutte contre le Cancer Oscar Lambret [Lille] [UNICANCER/Lille]
Centre hospitalier [Valenciennes, Nord]
Benoist, Stéphane [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Devos, Patrick [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Truant, Stéphanie [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Guimbaud, Rosine [Auteur]
Institut Claudius Regaud [ICR]
Lièvre, Astrid [Auteur]
Centre Hospitalier Universitaire de Rennes [CHU Rennes] = Rennes University Hospital [Pontchaillou]
Institut de Génétique et Développement de Rennes [IGDR]
Sefrioui, David [Auteur]
Communications Cellulaires et Différenciation [CCD]
Cohen, Romain [Auteur]
CHU Saint-Antoine [AP-HP]
Artru, Pascal [Auteur]
Hôpital privé Jean Mermoz [Lyon]
Dupré, Aurélien [Auteur]
Centre Léon Bérard [Lyon]
Bachet, Jean-Baptiste [Auteur]
CHU Pitié-Salpêtrière [AP-HP]
de La Fouchardière, Christelle [Auteur]
Centre Léon Bérard [Lyon]
Ploquin, Anne [Auteur]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Turpin, Anthony [Auteur correspondant]
Centre Hospitalier Régional Universitaire [CHU Lille] [CHRU Lille]
Hétérogénéité, Plasticité et Résistance aux Thérapies des Cancers = Cancer Heterogeneity, Plasticity and Resistance to Therapies - UMR 9020 - U 1277 [CANTHER]

Titre de la revue :

World Journal of Surgical Oncology

Pagination :

131

Éditeur :

BioMed Central

Date de publication :

2022-04-23

ISSN :

1477-7819

Mot(s)-clé(s) en anglais :

BRAF mutation
Colorectal cancer
Drug therapy
Liver metastasis surgery

Discipline(s) HAL :

Sciences du Vivant [q-bio]/Cancer

Résumé en anglais : [en]

BACKGROUND: BRAF V600E-mutant colorectal cancers (CRCs) are associated with shorter survival than BRAF wild-type tumors. Therapeutic decision-making for colorectal liver metastases (CRLM) harboring this mutation remains ...
Lire la suite >BACKGROUND: BRAF V600E-mutant colorectal cancers (CRCs) are associated with shorter survival than BRAF wild-type tumors. Therapeutic decision-making for colorectal liver metastases (CRLM) harboring this mutation remains difficult due to the scarce literature. The aim was to study a large cohort of BRAF V600E-mutant CRLM patients in order to see if surgery extend overall survival among others prognostic factors. METHODS: BRAF V600E-mutant CRCs diagnosed with liver-only metastases, resected or not, were retrospectively identified between April 2008 and December 2017, in 25 French centers. Clinical, molecular, pathological characteristics and treatment features were collected. Overall survival (OS) was defined as the time from CRLM diagnosis to death from any cause. Cox proportional hazard models were used for statistical analysis. RESULTS: Among the 105 patients included, 79 (75%) received chemotherapy, 18 (17%) underwent upfront CRLM surgery, and 8 (8%) received exclusive best supportive care. CRLM surgery was performed in 49 (46.7%) patients. CRLM were mainly synchronous (90%) with bilobar presentation (61%). The median OS was 34 months (range, 28.9-67.3 months) for resected patients and 10.6 (6.7-12.5) months for unresected patients (P < 0.0001). In multivariate analysis, primary tumor surgery (hazard ratio (HR) = 0.349; 95% confidence interval (CI) 0.164-0.744, P = 0.0064) and CRLM resection (HR = 0.169; 95% CI 0.082-0.348, P < 0.0001) were associated with significantly better OS. CONCLUSIONS: In the era of systemic cytotoxic chemotherapies, liver surgery seems to extend OS in BRAF V600E-mutant CRCs with liver only metastases historical cohort.Lire moins >

Langue :

Anglais

Comité de lecture :

Oui

Audience :

Internationale

Vulgarisation :

Non

Collections :

• Cancer Heterogeneity, Plasticity and Resistance to Therapies (CANTHER) - UMR 9020 - UMR 1277

Source :

Harvested from HAL