A Prospective International Study on ...
Type de document :
Article dans une revue scientifique
DOI :
PMID :
URL permanente :
Titre :
A Prospective International Study on Adherence to Treatment in 305 Patients With Flaring SLE: Assessment by Drug Levels and Self-Administered Questionnaires.
Auteur(s) :
Costedoat-Chalumeau, Nathalie [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Houssiau, Frederic [Auteur]
Izmirly, Peter [Auteur]
Le Guern, Veronique [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Navarra, Sandra [Auteur]
Jolly, Meenakshi [Auteur]
Ruiz-Irastorza, Guillermo [Auteur]
Baron, Gabriel [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Agmon-Levin, Nancy [Auteur]
Shoenfeld, Yehuda [Auteur]
Dall'ara, Francesca [Auteur]
Buyon, Jill [Auteur]
Deligny, Christophe [Auteur]
Cervera, Ricard [Auteur]
Lazaro, Estibaliz [Auteur]
Bezanahary, Holy [Auteur]
Leroux, Gaelle [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Morel, Nathalie [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Viallard, Jean-Francois [Auteur]
Pineau, Christian [Auteur]
Galicier, Lionel [Auteur]
Van Vollenhoven, Ronald [Auteur]
Tincani, Angela [Auteur]
Nguyen, Hanh [Auteur]
Gondran, Guillaume [Auteur]
Zahr, Noel [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Pouchot, Jacques [Auteur]
Piette, Jean-Charles [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Petri, Michelle [Auteur]
Isenberg, David [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Houssiau, Frederic [Auteur]
Izmirly, Peter [Auteur]
Le Guern, Veronique [Auteur]
Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité [CRESS (U1153 / UMR_A_1125 / UMR_S_1153)]
Navarra, Sandra [Auteur]
Jolly, Meenakshi [Auteur]
Ruiz-Irastorza, Guillermo [Auteur]
Baron, Gabriel [Auteur]
Université Paris Descartes - Paris 5 [UPD5]
Hachulla, Eric [Auteur]
Lille Inflammation Research International Center - U 995 [LIRIC]
Agmon-Levin, Nancy [Auteur]
Shoenfeld, Yehuda [Auteur]
Dall'ara, Francesca [Auteur]
Buyon, Jill [Auteur]
Deligny, Christophe [Auteur]
Cervera, Ricard [Auteur]
Lazaro, Estibaliz [Auteur]
Bezanahary, Holy [Auteur]
Leroux, Gaelle [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Morel, Nathalie [Auteur]
Centre for Research in Epidemiology and Statistics | Centre de Recherche Épidémiologie et Statistiques [CRESS (U1153 / UMR_A 1125)]
Viallard, Jean-Francois [Auteur]
Pineau, Christian [Auteur]
Galicier, Lionel [Auteur]
Van Vollenhoven, Ronald [Auteur]
Tincani, Angela [Auteur]
Nguyen, Hanh [Auteur]
Gondran, Guillaume [Auteur]
Zahr, Noel [Auteur]
Unité de Recherche sur les Maladies Cardiovasculaires, du Métabolisme et de la Nutrition = Research Unit on Cardiovascular and Metabolic Diseases [ICAN]
Pouchot, Jacques [Auteur]
Piette, Jean-Charles [Auteur]
Université Pierre et Marie Curie - Paris 6 [UPMC]
Petri, Michelle [Auteur]
Isenberg, David [Auteur]
Titre de la revue :
Clinical Pharmacology and Therapeutics
Nom court de la revue :
Clin. Pharmacol. Ther.
Numéro :
106
Pagination :
374-382
Date de publication :
2019-08
ISSN :
1532-6535
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half-life and can be quantified by high-performance liquid chromatography. ...
Lire la suite >Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half-life and can be quantified by high-performance liquid chromatography. This international study evaluated nonadherence in 305 lupus patients with flares using drug levels (HCQ < 200 ng/ml or undetectable desethylchloroquine), and self-administered questionnaires (MASRI < 80%). Drug levels defined 18.4% of the patients as severely nonadherent. In multivariate analyses, younger age, nonuse of steroids, higher body mass index, and unemployment were associated with nonadherence by drug level. Questionnaires classified 23.4% of patients as nonadherent. Correlations between adherence measured by questionnaires, drug level, and physician assessment were moderate. Both methods probably measured two different patterns of nonadherence: self-administered questionnaires mostly captured relatively infrequently missed tablets, while drug levels identified severe nonadherence (i.e., interruption or erratic tablet intake). The frequency with which physicians miss nonadherence, together with underreporting by patients, suggests that therapeutic drug monitoring is useful in this setting. (Trial registration: ClinicalTrials.gov: NCT01509989.).Lire moins >
Lire la suite >Nonadherence to treatment is a major cause of lupus flares. Hydroxychloroquine (HCQ), a major medication in systemic lupus erythematosus, has a long half-life and can be quantified by high-performance liquid chromatography. This international study evaluated nonadherence in 305 lupus patients with flares using drug levels (HCQ < 200 ng/ml or undetectable desethylchloroquine), and self-administered questionnaires (MASRI < 80%). Drug levels defined 18.4% of the patients as severely nonadherent. In multivariate analyses, younger age, nonuse of steroids, higher body mass index, and unemployment were associated with nonadherence by drug level. Questionnaires classified 23.4% of patients as nonadherent. Correlations between adherence measured by questionnaires, drug level, and physician assessment were moderate. Both methods probably measured two different patterns of nonadherence: self-administered questionnaires mostly captured relatively infrequently missed tablets, while drug levels identified severe nonadherence (i.e., interruption or erratic tablet intake). The frequency with which physicians miss nonadherence, together with underreporting by patients, suggests that therapeutic drug monitoring is useful in this setting. (Trial registration: ClinicalTrials.gov: NCT01509989.).Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
Inserm
Université de Lille
CHU Lille
Université de Lille
CHU Lille
Équipe(s) de recherche :
Immunity, inflammation and fibrsis in auto and allo-reactivity
Date de dépôt :
2019-03-01T14:17:42Z
2024-01-25T13:54:50Z
2024-01-25T13:54:50Z