Title :

Diagnostic accuracy of nipple aspirate fluid cytology in asymptomatic patients: a meta-analysis and systematic review of the literature

Author(s) :

Jiwa, Natasha [Auteur]
Gandhewar, Rishikesh [Auteur]
Chauhan, Hemali [Auteur]
Ashrafian, Hutan [Auteur]
Kumar, Swathica [Auteur]
Wright, Corrina [Auteur]
Takats, Zoltan [Auteur]
Imperial College London
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Leff, Daniel Richard [Auteur]
The Hamlyn Centre [London]

Journal title :

Annals of Surgical Oncology

Abbreviated title :

Ann. Surg. Oncol.

Volume number :

28

Publisher :

Springer Verlag

Publication date :

2020-11-09

ISSN :

1068-9265

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

PURPOSE: To calculate the diagnostic accuracy of nipple aspirate fluid (NAF) cytology. BACKGROUND: Evaluation of NAF cytology in asymptomatic patients conceptually offers a non-invasive method for either screening for ...
Show more >PURPOSE: To calculate the diagnostic accuracy of nipple aspirate fluid (NAF) cytology. BACKGROUND: Evaluation of NAF cytology in asymptomatic patients conceptually offers a non-invasive method for either screening for breast cancer or else predicting or stratifying future cancer risk. METHODS: Studies were identified by performing electronic searches up to August 2019. A meta-analysis was conducted to attain an overall pooled sensitivity and specificity of NAF for breast cancer detection. RESULTS: A search through 938 studies yielded a total of 19 studies. Overall, 9308 patients were examined, with cytology results from 10,147 breasts [age (years), mean +/- SD = 49.73 +/- 4.09 years]. Diagnostic accuracy meta-analysis of NAF revealed a pooled specificity of 0.97 (95% CI 0.97-0.98), and sensitivity of 0.64 (95% CI 0.62-0.66). CONCLUSIONS: The diagnostic accuracy of nipple smear cytology is limited by poor sensitivity. If nipple fluid assessment is to be used for diagnosis, then emerging technologies for fluid biomarker analysis must supersede the current diagnostic accuracy of NAF cytology.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

INSERM
Université de Lille

Collections :

• Autres travaux scientifiques
• Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192

Submission date :

2022-06-15T13:57:52Z
2023-04-12T09:06:09Z