Aif-1 and rnaset2 play complementary roles ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Aif-1 and rnaset2 play complementary roles in the innate immune response of medicinal leech
Auteur(s) :
Baranzini, Nicolo [Auteur]
Monti, Laura [Auteur]
Vanotti, Marta [Auteur]
Orlandi, Viviana T. [Auteur]
Bolognese, Fabrizio [Auteur]
Scaldaferri, Debora [Auteur]
Girardello, Rossana [Auteur]
Tettamanti, Gianluca [Auteur]
De Eguileor, Magda [Auteur]
Vizioli, Jacopo [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Taramelli, Roberto [Auteur]
Acquati, Francesco [Auteur]
Grimaldi, Annalisa [Auteur]
Monti, Laura [Auteur]
Vanotti, Marta [Auteur]
Orlandi, Viviana T. [Auteur]
Bolognese, Fabrizio [Auteur]
Scaldaferri, Debora [Auteur]
Girardello, Rossana [Auteur]
Tettamanti, Gianluca [Auteur]
De Eguileor, Magda [Auteur]
Vizioli, Jacopo [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Taramelli, Roberto [Auteur]
Acquati, Francesco [Auteur]
Grimaldi, Annalisa [Auteur]
Titre de la revue :
Journal of Innate Immunity
Nom court de la revue :
J. Innate Immun.
Numéro :
11
Pagination :
150-167
Date de publication :
2019-01-01
ISSN :
1662-811X
Mot(s)-clé(s) :
Allograft inflammatory factor-1
Leech innate immunity
Macrophages
Granulocytes
RNASET2
Leech innate immunity
Macrophages
Granulocytes
RNASET2
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
Recent studies demonstrated that allograft inflammatory factor-1 (AIF-1) and RNASET2 act as chemoattractants for macrophages and modulate the inflammatory processes in both vertebrates and invertebrates. The expression of ...
Lire la suite >Recent studies demonstrated that allograft inflammatory factor-1 (AIF-1) and RNASET2 act as chemoattractants for macrophages and modulate the inflammatory processes in both vertebrates and invertebrates. The expression of these proteins significantly increases after bacterial infection; however, the mechanisms by which they regulate the innate immune response are still poorly defined. Here, we evaluate the effect of bacterial lipopolysaccharide injection on the expression pattern of these genes and the interrelation between them during innate immune response in the medicinal leech, an invertebrate model with a simple anatomy and a marked similarity with vertebrates in inflammatory processes. Collectively, prokaryotic-eukaryotic co-cultures and in vivo infection assays suggest that RNASET2 and AIF-1 play a crucial role in orchestrating a functional cross-talk between granulocytes and macrophages in leeches, resulting in the activation of an effective response against pathogen infection. RNASET2, firstly released by granulocytes, likely plays an early antibacterial role. Subsequently, AIF-1+ RNASET2-recruited macrophages further recruit other macrophages to potentiate the antibacterial inflammatory response. These experimental data are in keeping with the notion of RNA-SET2 acting as an alarmin-like molecule whose role is to locally transmit a "danger" signal (such as a bacterial infection) to the innate immune system in order to trigger an appropriate host response.Lire moins >
Lire la suite >Recent studies demonstrated that allograft inflammatory factor-1 (AIF-1) and RNASET2 act as chemoattractants for macrophages and modulate the inflammatory processes in both vertebrates and invertebrates. The expression of these proteins significantly increases after bacterial infection; however, the mechanisms by which they regulate the innate immune response are still poorly defined. Here, we evaluate the effect of bacterial lipopolysaccharide injection on the expression pattern of these genes and the interrelation between them during innate immune response in the medicinal leech, an invertebrate model with a simple anatomy and a marked similarity with vertebrates in inflammatory processes. Collectively, prokaryotic-eukaryotic co-cultures and in vivo infection assays suggest that RNASET2 and AIF-1 play a crucial role in orchestrating a functional cross-talk between granulocytes and macrophages in leeches, resulting in the activation of an effective response against pathogen infection. RNASET2, firstly released by granulocytes, likely plays an early antibacterial role. Subsequently, AIF-1+ RNASET2-recruited macrophages further recruit other macrophages to potentiate the antibacterial inflammatory response. These experimental data are in keeping with the notion of RNA-SET2 acting as an alarmin-like molecule whose role is to locally transmit a "danger" signal (such as a bacterial infection) to the innate immune system in order to trigger an appropriate host response.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
INSERM
Université de Lille
Université de Lille
Date de dépôt :
2022-06-15T13:58:45Z