Response assessment of meningioma: 1d, 2d ...
Type de document :
Article dans une revue scientifique: Article original
DOI :
PMID :
URL permanente :
Titre :
Response assessment of meningioma: 1d, 2d and volumetric criteria for treatment response and tumor progression
Auteur(s) :
Huang, Raymond Y. [Auteur]
Unadkat, Prashin [Auteur]
Linda Bi, Wenya [Auteur]
George, Elizabeth [Auteur]
Preusser, Matthias [Auteur]
Mccracken, D. Jay [Auteur]
Keen, Joseph R. [Auteur]
Read, William L. [Auteur]
Olson, Jeffrey J. [Auteur]
Seystahl, Katharina [Auteur]
Le Rhun, Emilie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Roelcke, Ulrich [Auteur]
Koeppen, Susanne [Auteur]
Furtner, Julia [Auteur]
Weller, Michael [Auteur]
Raizer, Jeffrey J. [Auteur]
Schiff, David [Auteur]
Wen, Patrick Y. [Auteur]
Unadkat, Prashin [Auteur]
Linda Bi, Wenya [Auteur]
George, Elizabeth [Auteur]
Preusser, Matthias [Auteur]
Mccracken, D. Jay [Auteur]
Keen, Joseph R. [Auteur]
Read, William L. [Auteur]
Olson, Jeffrey J. [Auteur]
Seystahl, Katharina [Auteur]
Le Rhun, Emilie [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Roelcke, Ulrich [Auteur]
Koeppen, Susanne [Auteur]
Furtner, Julia [Auteur]
Weller, Michael [Auteur]
Raizer, Jeffrey J. [Auteur]
Schiff, David [Auteur]
Wen, Patrick Y. [Auteur]
Titre de la revue :
Neuro-Oncology
Nom court de la revue :
Neuro-oncology
Date de publication :
2018-08-02
ISSN :
1523-5866
Mot(s)-clé(s) :
survival
MRI
response
volume
meningioma
MRI
response
volume
meningioma
Discipline(s) HAL :
Sciences du Vivant [q-bio]
Résumé en anglais : [en]
BACKGROUND: Meningiomas are the most common primary brain tumors in adults. Due to their variable growth rates and irregular tumor shapes, response assessment in clinical trials remains challenging and no standard criteria ...
Lire la suite >BACKGROUND: Meningiomas are the most common primary brain tumors in adults. Due to their variable growth rates and irregular tumor shapes, response assessment in clinical trials remains challenging and no standard criteria have been defined. We evaluated 1D, 2D, and volume imaging criteria to assess whether a volumetric approach might be a superior surrogate for overall survival (OS). METHODS: In this retrospective multicenter study, we evaluated the clinical and imaging data of 93 patients with recurrent meningiomas treated with pharmacotherapy. One-dimensional (1D), 2D, and volumetric measurements of enhancing tumor on pre- and post-treatment MRI were compared at 6 and 12 months after treatment initiation. Cox proportional hazards models were used to examine the relationship between each imaging criterion and OS. RESULTS: The median age of the patient cohort is 51 years (range 12-88), with 14 World Health Organization (WHO) grade I, 53 WHO grade II, and 26 WHO grade III meningiomas. Volumetric increase of 40% and unidimensional increase by 10 mm at 6 months and 12 months provided the strongest association with overall survival (HR = 2.58 and 3.24 respectively, p<0.01). Setting a volume change threshold above 40% did not correlate with survival. The interobserver agreement of 1D, 2D, and volume criteria is only moderate (kappa = 0.49, 0.46, 0.52, respectively). None of the criteria based on tumor size reduction were associated with OS (P > 0.09). CONCLUSION: Compared with 1D (Response Evaluation Criteria In Solid Tumors 1.1) and 2D (Response Assessment in Neuro-Oncology) approaches, volumetric criteria for tumor progression has a stronger association with OS, although the differences were only modest. The interobserver variability is moderate for all 3 methods. Further validation of these findings in an independent patient cohort is needed.Lire moins >
Lire la suite >BACKGROUND: Meningiomas are the most common primary brain tumors in adults. Due to their variable growth rates and irregular tumor shapes, response assessment in clinical trials remains challenging and no standard criteria have been defined. We evaluated 1D, 2D, and volume imaging criteria to assess whether a volumetric approach might be a superior surrogate for overall survival (OS). METHODS: In this retrospective multicenter study, we evaluated the clinical and imaging data of 93 patients with recurrent meningiomas treated with pharmacotherapy. One-dimensional (1D), 2D, and volumetric measurements of enhancing tumor on pre- and post-treatment MRI were compared at 6 and 12 months after treatment initiation. Cox proportional hazards models were used to examine the relationship between each imaging criterion and OS. RESULTS: The median age of the patient cohort is 51 years (range 12-88), with 14 World Health Organization (WHO) grade I, 53 WHO grade II, and 26 WHO grade III meningiomas. Volumetric increase of 40% and unidimensional increase by 10 mm at 6 months and 12 months provided the strongest association with overall survival (HR = 2.58 and 3.24 respectively, p<0.01). Setting a volume change threshold above 40% did not correlate with survival. The interobserver agreement of 1D, 2D, and volume criteria is only moderate (kappa = 0.49, 0.46, 0.52, respectively). None of the criteria based on tumor size reduction were associated with OS (P > 0.09). CONCLUSION: Compared with 1D (Response Evaluation Criteria In Solid Tumors 1.1) and 2D (Response Assessment in Neuro-Oncology) approaches, volumetric criteria for tumor progression has a stronger association with OS, although the differences were only modest. The interobserver variability is moderate for all 3 methods. Further validation of these findings in an independent patient cohort is needed.Lire moins >
Langue :
Anglais
Audience :
Internationale
Vulgarisation :
Non
Établissement(s) :
INSERM
Université de Lille
Université de Lille
Date de dépôt :
2022-06-15T13:58:51Z
2023-04-21T15:12:08Z
2023-04-21T15:12:08Z