Spinal cord injury: animal models, imaging ...
Document type :
Article dans une revue scientifique: Article original
PMID :
Permalink :
Title :
Spinal cord injury: animal models, imaging tools and the treatment strategies
Author(s) :
Cizkova, Dasa [Auteur]
Murgoci, Adriana-Natalia [Auteur]
Cubinkova, Veronika [Auteur]
Humenik, Filip [Auteur]
Mojzisova, Zuzana [Auteur]
Maloveska, Marcela [Auteur]
Cizek, Milan [Auteur]
FOURNIER, Isabelle [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Salzet, Michel [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Murgoci, Adriana-Natalia [Auteur]
Cubinkova, Veronika [Auteur]
Humenik, Filip [Auteur]
Mojzisova, Zuzana [Auteur]
Maloveska, Marcela [Auteur]
Cizek, Milan [Auteur]
FOURNIER, Isabelle [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Salzet, Michel [Auteur]
Protéomique, Réponse Inflammatoire, Spectrométrie de Masse (PRISM) - U1192
Journal title :
Neurochemical research
Abbreviated title :
Neurochem. Res.
Publication date :
2019-04-20
ISSN :
1573-6903
Keyword(s) :
Animal models
Biomaterials
Exosomes
Stem cells
Imaging
Spinal cord injury
Biomaterials
Exosomes
Stem cells
Imaging
Spinal cord injury
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Spinal cord injury (SCI) often leads to irreversible neuro-degenerative changes with life-long consequences. While there is still no effective therapy available, the results of past research have led to improved quality ...
Show more >Spinal cord injury (SCI) often leads to irreversible neuro-degenerative changes with life-long consequences. While there is still no effective therapy available, the results of past research have led to improved quality of life for patients suffering from partial or permanent paralysis. In this review we focus on the need, importance and the scientific value of experimental animal models simulating SCI in humans. Furthermore, we highlight modern imaging tools determining the location and extent of spinal cord damage and their contribution to early diagnosis and selection of appropriate treatment. Finally, we focus on available cellular and acellular therapies and novel combinatory approaches with exosomes and active biomaterials. Here we discuss the efficacy and limitations of adult mesenchymal stem cells which can be derived from bone marrow, adipose tissue or umbilical cord blood and its Wharton's jelly. Special attention is paid to stem cell-derived exosomes and smart biomaterials due to their special properties as a delivery system for proteins, bioactive molecules or even genetic material.Show less >
Show more >Spinal cord injury (SCI) often leads to irreversible neuro-degenerative changes with life-long consequences. While there is still no effective therapy available, the results of past research have led to improved quality of life for patients suffering from partial or permanent paralysis. In this review we focus on the need, importance and the scientific value of experimental animal models simulating SCI in humans. Furthermore, we highlight modern imaging tools determining the location and extent of spinal cord damage and their contribution to early diagnosis and selection of appropriate treatment. Finally, we focus on available cellular and acellular therapies and novel combinatory approaches with exosomes and active biomaterials. Here we discuss the efficacy and limitations of adult mesenchymal stem cells which can be derived from bone marrow, adipose tissue or umbilical cord blood and its Wharton's jelly. Special attention is paid to stem cell-derived exosomes and smart biomaterials due to their special properties as a delivery system for proteins, bioactive molecules or even genetic material.Show less >
Language :
Anglais
Audience :
Internationale
Popular science :
Non
Administrative institution(s) :
INSERM
Université de Lille
Université de Lille
Submission date :
2022-06-15T13:59:21Z