Synthesis and Self-Assembly of UV-Cross-Linkable ...
Document type :
Article dans une revue scientifique: Article original
Permalink :
Title :
Synthesis and Self-Assembly of UV-Cross-Linkable Amphiphilic Polyoxazoline Block Copolymers: Importance of Multitechnique Characterization
Author(s) :
Belkhir, Kedafi [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Cerlati, Orélia [Auteur]
Heaugwane, Diana [Auteur]
Tosi, Alice [Auteur]
Benkhaled, Belkacem Tarek [Auteur]
Brient, Pierre-Louis [Auteur]
Chatard, Camille [Auteur]
Graillot, Alain [Auteur]
Catrouillet, Sylvain [Auteur]
Balor, Stéphanie [Auteur]
Goudounèche, Dominique [Auteur]
Payré, Bruno [Auteur]
Laborie, Pascale [Auteur]
Lim, Jia-Hui [Auteur]
Putaux, Jean-Luc [Auteur]
Vicendo, Patricia [Auteur]
Gibot, Laure [Auteur]
Lonetti, Barbara [Auteur]
Mingotaud, Anne-Françoise [Auteur]
Lapinte, Vincent [Auteur]
Unité Matériaux et Transformations (UMET) - UMR 8207
Cerlati, Orélia [Auteur]
Heaugwane, Diana [Auteur]
Tosi, Alice [Auteur]
Benkhaled, Belkacem Tarek [Auteur]
Brient, Pierre-Louis [Auteur]
Chatard, Camille [Auteur]
Graillot, Alain [Auteur]
Catrouillet, Sylvain [Auteur]
Balor, Stéphanie [Auteur]
Goudounèche, Dominique [Auteur]
Payré, Bruno [Auteur]
Laborie, Pascale [Auteur]
Lim, Jia-Hui [Auteur]
Putaux, Jean-Luc [Auteur]
Vicendo, Patricia [Auteur]
Gibot, Laure [Auteur]
Lonetti, Barbara [Auteur]
Mingotaud, Anne-Françoise [Auteur]
Lapinte, Vincent [Auteur]
Journal title :
Langmuir
Abbreviated title :
Langmuir
Volume number :
38
Pages :
16144-16155
Publisher :
American Chemical Society (ACS)
Publication date :
2022-12-14
English abstract : [en]
In the nanomedicine field, there is a need to widen the availability of nanovectors to compensate for the increasingly reported side effects of poly(ethene glycol). Nanovectors enabling cross-linking can further optimize ...
Show more >In the nanomedicine field, there is a need to widen the availability of nanovectors to compensate for the increasingly reported side effects of poly(ethene glycol). Nanovectors enabling cross-linking can further optimize drug delivery. Cross-linkable polyoxazolines are therefore relevant candidates to address these two points. Here we present the synthesis of coumarin-functionalized poly(2-alkyl-2-oxazoline) block copolymers, namely, poly(2-methyl-2-oxazoline)-block-poly(2-phenyl-2-oxazoline) and poly(2-methyl-2-oxazoline)-block-poly(2-butyl-2-oxazoline). The hydrophilic ratio and molecular weights were varied in order to obtain a range of possible behaviors. Their self-assembly after nanoprecipitation or film rehydration was examined. The resulting nano-objects were fully characterized by transmission electron microscopy (TEM), cryo-TEM, multiple-angle dynamic and static light scattering. In most cases, the formation of polymer micelles was observed, as well as, in some cases, aggregates, which made characterization more difficult. Cross-linking was performed under UV illumination in the presence of a coumarin-bearing cross-linker based on polymethacrylate derivatives. Addition of the photo-cross-linker and cross-linking resulted in better-defined objects with improved stability in most cases.Show less >
Show more >In the nanomedicine field, there is a need to widen the availability of nanovectors to compensate for the increasingly reported side effects of poly(ethene glycol). Nanovectors enabling cross-linking can further optimize drug delivery. Cross-linkable polyoxazolines are therefore relevant candidates to address these two points. Here we present the synthesis of coumarin-functionalized poly(2-alkyl-2-oxazoline) block copolymers, namely, poly(2-methyl-2-oxazoline)-block-poly(2-phenyl-2-oxazoline) and poly(2-methyl-2-oxazoline)-block-poly(2-butyl-2-oxazoline). The hydrophilic ratio and molecular weights were varied in order to obtain a range of possible behaviors. Their self-assembly after nanoprecipitation or film rehydration was examined. The resulting nano-objects were fully characterized by transmission electron microscopy (TEM), cryo-TEM, multiple-angle dynamic and static light scattering. In most cases, the formation of polymer micelles was observed, as well as, in some cases, aggregates, which made characterization more difficult. Cross-linking was performed under UV illumination in the presence of a coumarin-bearing cross-linker based on polymethacrylate derivatives. Addition of the photo-cross-linker and cross-linking resulted in better-defined objects with improved stability in most cases.Show less >
Language :
Anglais
Peer reviewed article :
Oui
Audience :
Non spécifiée
Administrative institution(s) :
Université de Lille
CNRS
INRAE
ENSCL
CNRS
INRAE
ENSCL
Collections :
Submission date :
2023-01-07T04:00:02Z