Title :

3D printed PLGA implants: APF DDM vs. FDM.

Author(s) :

Bassand, Celine [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Benabed, L. [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Charlon, S. [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Lille Douai]
Verin, Jérémy [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Freitag, J. [Auteur]
Médicaments et biomatériaux à libération contrôlée: mécanismes et optimisation - Advanced Drug Delivery Systems - U 1008 [MBLC - ADDS]
Siepmann, Florence [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008
Soulestin, J. [Auteur]
Ecole nationale supérieure Mines-Télécom Lille Douai [IMT Lille Douai]
Siepmann, Juergen [Auteur]
Advanced Drug Delivery Systems (ADDS) - U1008

Journal title :

Journal of Controlled Release

Abbreviated title :

J Control Release

Volume number :

353

Pages :

864-874

Publisher :

Elsevier

Publication date :

2022-12-19

ISSN :

1873-4995

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

3D Printing offers a considerable potential for personalized medicines. This is especially true for customized biodegradable implants, matching the specific needs of each patient. Poly(lactic-co-glycolic acid) (PLGA) is ...
Show more >3D Printing offers a considerable potential for personalized medicines. This is especially true for customized biodegradable implants, matching the specific needs of each patient. Poly(lactic-co-glycolic acid) (PLGA) is frequently used as matrix former in biodegradable implants. However, yet relatively little is known on the technologies, which can be used for the 3D printing of PLGA implants. The aim of this study was to compare: (i) Arburg Plastic Freeforming Droplet Deposition Modeling (APF DDM), and (ii) Fused Deposition Modeling (FDM) to print mesh-shaped, ibuprofen-loaded PLGA implants. During APF DDM, individual drug-polymer droplets are deposited, fusing together to form filaments, which build up the implants. During FDM, continuous drug-polymer filaments are deposited to form the meshes. The implants were thoroughly characterized before and after exposure to phosphate buffer pH 7.4 using optical and scanning electron microscopy, GPC, DSC, drug release measurements and monitoring dynamic changes in the systems' dry & wet mass and pH of the bulk fluid. Interestingly, the mesh structures were significantly different, although the device design (composition & theoretical geometry) were the same. This could be explained by the fact that the deposition of individual droplets during APF DDM led to curved and rather thick filaments, resulting in a much lower mesh porosity. In contrast, FDM printing generated straight and thinner filaments: The open spaces between them were much larger and allowed convective mass transport during drug release. Consequently, most of the drug was already released after 4 d, when substantial PLGA set on. In the case of APF DDM printed implants, most of the drug was still entrapped at that time point and substantial polymer swelling transformed the meshes into more or less continuous PLGA gels. Hence, the diffusion pathways became much longer and ibuprofen release was controlled over 2 weeks.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Advanced Drug Delivery Systems (ADDS) - U1008

Submission date :

2023-02-22T01:29:37Z
2023-03-03T10:49:37Z