Title :

Outcome of long gap esophageal atresia at 6 years: A prospective case control cohort study

Author(s) :

Bourg, Agate [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
gottrand, Fréderic [Auteur]
Lille Inflammation Research International Center (LIRIC) - U995
Parmentier, Benoit [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Thomas, Julie [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Lehn, Anne [Auteur]
Centre Hospitalier Universitaire [Strasbourg] [CHU Strasbourg]
Piolat, Christian [Auteur]
Service de chirurgie pédiatrique [CHU Grenoble]
Bonnard, Arnaud [Auteur]
AP-HP Hôpital universitaire Robert-Debré [Paris]
Sfeir, Rony [Auteur]
Institute for Translational Research in Inflammation - U 1286 [INFINITE]
Lienard, Julie [Auteur]
Centre Hospitalier Universitaire de Nancy [CHU Nancy]
Rousseau, Véronique [Auteur]
Hôpital Necker - Enfants Malades [AP-HP]
Pouzac, Myriam [Auteur]
Centre Hospitalier Régional d'Orléans [CHRO]
Liard, Agnès [Auteur]
CHU Rouen
Buisson, Philippe [Auteur]
CHU Amiens-Picardie
Haffreingue, Aurore [Auteur]
CHU Caen
David, Louis [Auteur]
Université Lille Nord (France)
Branchereau, Sophie [Auteur]
Hôpital Bicêtre [AP-HP, Le Kremlin-Bicêtre]
Carcauzon, Véronique [Auteur]
Centre Hospitalier Le Mans (CH Le Mans)
Kalfa, Nicolas [Auteur]
Hôpital Lapeyronie [CHU Montpellier]
Leclair, Marc-David [Auteur]
Centre Hospitalier Universitaire de Nantes = Nantes University Hospital [CHU Nantes]
Lardy, Hubert [Auteur]
Centre Hospitalier Régional Universitaire de Tours [CHRU Tours]
Irtan, Sabine [Auteur]
CHU Trousseau [APHP]
Varlet, François [Auteur]

Gelas, Thomas [Auteur]
Centre Hospitalier Lyon Sud [CHU - HCL] [CHLS]
Potop, Diana [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]
Auger-Hunault, Marie [Auteur]
Centre hospitalier universitaire de Poitiers = Poitiers University Hospital [CHU de Poitiers [La Milétrie]]

Journal title :

Journal of Pediatric Surgery

Abbreviated title :

Journal of Pediatric Surgery

Publisher :

Elsevier BV

Publication date :

2022-08

ISSN :

0022-3468

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Background data: EA is the most frequent congenital esophageal malformation. Long gap EA remains a therapeutic challenge for pediatric surgeons. A case case-control prospective study from a multi-institutional national ...
Show more >Background data: EA is the most frequent congenital esophageal malformation. Long gap EA remains a therapeutic challenge for pediatric surgeons. A case case-control prospective study from a multi-institutional national French data base was performed to assess the outcome, at age of 1 and 6 years, of long gap esophageal atresia (EA) compared with non-long gap EA/tracheo-esophageal fistula (TEF). The secondary aim was to assess whether initial treatment (delayed primary anastomosis of native esophagus vs. esophageal replacement) influenced mortality and morbidity at ages 1 and 6 years. Methods: A multicentric population-based prospective study was performed and included all patients who underwent EA surgery in France from January 1, 2008 to December 31, 2010. A comparative study was performed with non-long gap EA/TEF patients. Morbidity at birth, 1 year, and 6 years was assessed. Results: Thirty-one patients with long gap EA were compared with 62 non-long gap EA/TEF patients. At age 1 year, the long gap EA group had longer parenteral nutrition support and longer hospital stay and were significantly more likely to have complications both early post-operatively and before age 1 year compared with the non-long gap EA/TEF group. At 6 years, digestive complications were more frequent in long gap compared to non-long gap EA/TEF patients. Tracheomalacia was the only respiratory complication that differed between the groups. Spine deformation was less frequent in the long gap group. There were no differences between conservative and replacement groups at ages 1 and 6 years except feeding difficulties that were more common in the native esophagus group. Conclusions: Long gap strongly influenced digestive morbidity at age 6 years. Keywords: Complications; Dysphagia; Esophageal atresia; Esophageal replacement; Gastro-esophageal reflux disease; Long gap esophageal atresia; Midterm outcomes.Show less >

Language :

Anglais

Audience :

Internationale

Administrative institution(s) :

Université de Lille
Inserm
CHU Lille

Collections :

• Institut de Recherche Translationnelle sur l'Inflammation (INFINITE) - U1286

Submission date :

2023-03-09T13:18:40Z
2023-03-15T09:31:10Z