Title :

Role of cationic channel TRPV2 in promoting prostate cancer migration and progression to androgen resistance

Author(s) :

Monet, Michaël [Auteur]
Université Paris Descartes - Faculté de Médecine [UPD5 Médecine]
Lehen'Kyi, V'Yacheslav [Auteur]
Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate
Gackiere, Florian [Auteur]
Centre de recherche en neurobiologie - neurophysiologie de Marseille [CRN2M]
Firlej, Virginie [Auteur]
Institut Cochin [IC UM3 (UMR 8104 / U1016)]
Vandenberghe, Matthieu [Auteur]
Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate
Roudbaraki, Morad [Auteur]
Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate
Gkika, Dimitra [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Pourtier, Albin [Auteur]
Institut de biologie de Lille - IBL [IBLI]
Bidaux, Gabriel [Auteur]
Laboratoire de Physique des Lasers, Atomes et Molécules - UMR 8523 [PhLAM]
Slomianny, Christian [Auteur]
Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate
Delcourt, philippe [Auteur]
Laboratoire de Physiologie Cellulaire - U 1003 [PHYCELL]
Rassendren, François [Auteur]
Institut de Génomique Fonctionnelle [IGF]
Bergerat, Jean-Pierre [Auteur]
Altération génétique des cancers, chimioprévention et réponse thérapeutique
Ceraline, Jocelyn [Auteur]
Progression tumorale et microenvironnement. Approches translationnelles et épidémiologie
Cabon, Florence [Auteur]
Humez, Sandrine [Auteur]
Centre de Recherche Jean-Pierre AUBERT Neurosciences et Cancer - U837 [JPArc]
Prevarskaya, Natalia [Auteur]
Rôle des canaux ioniques membranaires et du calcium intracellulaire dans la physiopathologie de la prostate

Journal title :

Cancer Research

Pages :

9410-9419

Publisher :

American Association for Cancer Research

Publication date :

2010-03

ISSN :

0008-5472

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Abstract Castration resistance in prostate cancer (PCa) constitutes an advanced, aggressive disease with poor prognosis, associated with uncontrolled cell proliferation, resistance to apoptosis, and enhanced invasive ...
Show more >Abstract Castration resistance in prostate cancer (PCa) constitutes an advanced, aggressive disease with poor prognosis, associated with uncontrolled cell proliferation, resistance to apoptosis, and enhanced invasive potential. The molecular mechanisms involved in the transition of PCa to castration resistance are obscure. Here, we report that the nonselective cationic channel transient receptor potential vanilloid 2 (TRPV2) is a distinctive feature of castration-resistant PCa. TRPV2 transcript levels were higher in patients with metastatic cancer (stage M1) compared with primary solid tumors (stages T2a and T2b). Previous studies of the TRPV2 channel indicated that it is primarily involved in cancer cell migration and not in cell growth. Introducing TRPV2 into androgen-dependent LNCaP cells enhanced cell migration along with expression of invasion markers matrix metalloproteinase (MMP) 9 and cathepsin B. Consistent with the likelihood that TRPV2 may affect cancer cell aggressiveness by influencing basal intracellular calcium levels, small interfering RNA–mediated silencing of TRPV2 reduced the growth and invasive properties of PC3 prostate tumors established in nude mice xenografts, and diminished expression of invasive enzymes MMP2, MMP9, and cathepsin B. Our findings establish a role for TRPV2 in PCa progression to the aggressive castration-resistant stage, prompting evaluation of TRPV2 as a potential prognostic marker and therapeutic target in the setting of advanced PCa. Cancer Res; 70(3); 1225–35Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Collections :

• Laboratoire de Physique des Lasers, Atomes et Molécules (PhLAM) - UMR 8523

Source :

Harvested from HAL