Dynamic particle count during drug infusion: ...
Document type :
Article dans une revue scientifique: Article original
Permalink :
Title :
Dynamic particle count during drug infusion: Method characterization and analysis of factors influencing results
Author(s) :
Martin Mena, Anthony [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - EA 7365
Masse, Morgane [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Negrier, Laura [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Carta, Natacha [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Pettinari, Alice [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Barthelemy, Christine [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Odou, Pascal [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
GENAY, Stéphanie [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Décaudin, Bertrand [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - EA 7365
Masse, Morgane [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Negrier, Laura [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Carta, Natacha [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Pettinari, Alice [Auteur]
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Barthelemy, Christine [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Odou, Pascal [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
GENAY, Stéphanie [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées - ULR 7365 [GRITA]
Décaudin, Bertrand [Auteur]
![refId](/themes/Mirage2//images/idref.png)
Groupe de Recherche sur les formes Injectables et les Technologies Associées (GRITA) - ULR 7365
Journal title :
Journal of Drug Delivery Science and Technology
Abbreviated title :
J. Drug Deliv. Sci. Technol.
Volume number :
55
Pages :
101473
Publisher :
Elsevier
Publication date :
2020-03-28
ISSN :
1773-2247
Keyword(s) :
Drug incompatibility
Subvisible particles
Particle size
Dynamic particle count
Drug infusion systems
Particulate matter
Subvisible particles
Particle size
Dynamic particle count
Drug infusion systems
Particulate matter
HAL domain(s) :
Sciences du Vivant [q-bio]
English abstract : [en]
Introduction
Drug incompatibilities are a constant problem in hospital care units. The multiplication of drugs injected simultaneously during patient therapy increases the risk of incompatibilities and can have a ...
Show more >Introduction Drug incompatibilities are a constant problem in hospital care units. The multiplication of drugs injected simultaneously during patient therapy increases the risk of incompatibilities and can have a significant clinical impact. The purpose of this research was to characterize and analyze various parameters inducing variability in particle counting using a dynamic particle counter. Materials and methods Observations were performed on two-ports manifolds with two incompatible drugs, thus creating a quantifiable particulate charge. We analyzed the number of different-sized particles measured during the experiment as well as their cumulative distribution. The parameters studied on particle count were: position of the infusion device, environmental vibrations and total flow rate. Results Significantly higher particle counts were observed when the infusion device was in a vertical position or disturbed by vibrations. Total flow rate significantly reduced the number of particles. Conclusion This study enabled us to identify several variation factors through dynamic particle counting. These factors should be taken into account to reduce variability in results.Show less >
Show more >Introduction Drug incompatibilities are a constant problem in hospital care units. The multiplication of drugs injected simultaneously during patient therapy increases the risk of incompatibilities and can have a significant clinical impact. The purpose of this research was to characterize and analyze various parameters inducing variability in particle counting using a dynamic particle counter. Materials and methods Observations were performed on two-ports manifolds with two incompatible drugs, thus creating a quantifiable particulate charge. We analyzed the number of different-sized particles measured during the experiment as well as their cumulative distribution. The parameters studied on particle count were: position of the infusion device, environmental vibrations and total flow rate. Results Significantly higher particle counts were observed when the infusion device was in a vertical position or disturbed by vibrations. Total flow rate significantly reduced the number of particles. Conclusion This study enabled us to identify several variation factors through dynamic particle counting. These factors should be taken into account to reduce variability in results.Show less >
Language :
Anglais
Audience :
Internationale
Administrative institution(s) :
Université de Lille
CHU Lille
CHU Lille
Collections :
Submission date :
2023-05-25T03:56:30Z
2023-09-13T07:09:38Z
2023-09-13T07:09:38Z