Titre :

Structure-function analysis of DltE reveals D-alanylated lipoteichoic acids as direct cues supporting juvenile growth.

Auteur(s) :

Nikolopoulos, Nikos [Auteur]
Matos, Renata C [Auteur]
Ravaud, Stephanie [Auteur]
Courtin, Pascal [Auteur]
Akherraz, Houssam [Auteur]
Palussiere, Simon [Auteur]
Gueguen-Chaignon, Virginie [Auteur]
Salomon-Mallet, Marie [Auteur]
Guillot, Alain [Auteur]
Guerardel, Yann [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Chapot-Chartier, Marie-Pierre [Auteur]
Grangeasse, Christophe [Auteur]
Leulier, François [Auteur]

Titre de la revue :

eLife

Nom court de la revue :

Elife

Numéro :

12

Date de publication :

2023-04-12

ISSN :

2050-084X

Mot(s)-clé(s) en anglais :

Animals
Drosophila
Drosophila melanogaster
Teichoic Acids
Cues
Lipopolysaccharides
Biological Phenomena
D. melanogaster
Lactiplantibacillus plantarum
cell wall
infectious disease
lipoteichoic acids
microbiology
symbiosis

Discipline(s) HAL :

Sciences du Vivant [q-bio]

Résumé en anglais : [en]

Metazoans establish mutually beneficial interactions with their resident microorganisms. However, our understanding of the microbial cues contributing to host physiology remains elusive. Previously, we identified a bacterial ...
Lire la suite >Metazoans establish mutually beneficial interactions with their resident microorganisms. However, our understanding of the microbial cues contributing to host physiology remains elusive. Previously, we identified a bacterial machinery encoded by the operon involved in 's juvenile growth promotion by . Here, using crystallography combined with biochemical and cellular approaches, we investigate the physiological role of an uncharacterized protein (DltE) encoded by this operon. We show that lipoteichoic acids (LTAs) but not wall teichoic acids are D-alanylated in cell envelope and demonstrate that DltE is a D-Ala carboxyesterase removing D-Ala from LTA. Using the mutualistic association of and as a symbiosis model, we establish that D-alanylated LTAs (D-Ala-LTAs) are direct cues supporting intestinal peptidase expression and juvenile growth in . Our results pave the way to probing the contribution of D-Ala-LTAs to host physiology in other symbiotic models.Lire moins >

Langue :

Anglais

Audience :

Non spécifiée

Établissement(s) :

Université de Lille
CNRS

Collections :

• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Équipe(s) de recherche :

Chemical Glycobiology

Date de dépôt :

2023-07-19T08:39:29Z