Title :

Interpretation of hair and nails findings in an infant death case related to maternal addiction to tramadol.

Author(s) :

Gish, Alexandr [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Richeval, Camille [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Wiart, J. F. [Auteur]
Hennart, Benjamin [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Hakim, Florian [Auteur]
Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS]
Demarly, C. [Auteur]
Balgairies, A. [Auteur]
Hedouin, Valery [Auteur]
Unité de Taphonomie médico-légale et Anatomie - ULR 7367 [UTML&A]
Allorge, Delphine [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483
Gaulier, Jean-Michel [Auteur]
IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Journal title :

Drug Testing and Analysis

Abbreviated title :

Drug Test Anal

Volume number :

15

Pages :

1022-1026

Publisher :

Wiley

Publication date :

2023-04-29

ISSN :

1942-7611

English keyword(s) :

hair
infant
intoxication
nails
tramadol

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

An 11-month-old boy was found dead. Autopsy findings (cyanosis and polyvisceral congestion) and blood tramadol (TR) concentration of 6240 μg/L were consistent with an acute TR intoxication. In this poisoning situation, ...
Show more >An 11-month-old boy was found dead. Autopsy findings (cyanosis and polyvisceral congestion) and blood tramadol (TR) concentration of 6240 μg/L were consistent with an acute TR intoxication. In this poisoning situation, owing to the mother's statements (TR addiction leading to daily TR-orange juice mixture preparation accidentally used for the baby bottle preparation by the mother's partner), and the question of possible previous TR administrations to the infant, hair and/or nails (infant, mother, partner, 6-year-old sister) analysis was performed. Hair (2-cm-long hair segments from proximal [S1] to distal [S3]) and nails concentrations (pg/mg; nd: not detected) were as follows: Infant (hair: TR 1420 [S1], 1622 [S2], 2736 [S3]; O-DMT 16–38; N-DMT 34–100 [TR in significant quantities in the hair decontamination bath]—toenails: TR 584; O-DMT 8; N-DMT 15), mother (hair: TR 2340 [S1], 2150 [S2], 2500 [S3]; O-DMT 704–1170; N-DMT 827–1360), mother's partner (fingernails: TR 72; O-DMT nd; N-DMT nd) and sister (hair: TR 261 [S1], 524 [S2]; O-DMT 15 [S1], 16 [S2]; N-DMT 20 [S1], 38 [S2]). Metabolite ratio (infant and sister hair) was comparable to those observed in hair of pharmaceutical industry employees manufacturing tramadol. TR in washing baths, low observed nail concentrations (infant and partner) confirm (i) TR-related mother's addiction and (ii) external contamination issues (TR in sweat of the child at the time of death and in living environment) to explain the infant's keratinized samples results. This case report illustrates the interest of analyzing keratinized matrices of the whole family in such a situation.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille
Institut Pasteur de Lille

Collections :

• IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483

Submission date :

2023-10-20T05:48:57Z
2024-02-28T09:35:04Z