Title :

Increased risk of severe COVID-19 in hospitalized patients with SARS-CoV-2 Alpha variant infection: a multicentre matched cohort study

Author(s) :

Martin-Blondel, Guillaume [Auteur]
Institut Toulousain des Maladies Infectieuses et Inflammatoires [Infinity]
Centre Hospitalier Universitaire de Toulouse [CHU Toulouse]
Lescure, François-Xavier [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Assoumou, Lambert [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Charpentier, Charlotte [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Chapplain, Jean-Marc [Auteur]
Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes]
Perpoint, Thomas [Auteur]
Service des Maladies Infectieuses et Tropicales [Lyon]
Grouteau, Gaspard [Auteur]
Service Maladies infectieuses et tropicales [CHU Toulouse]
Cordel, Hugues [Auteur]
Service de maladies infectieuses et tropicales [CHU Avicenne]
Pialoux, Gilles [Auteur]
CHU Tenon [AP-HP]
Pacanowski, Jérome [Auteur]
CHU Saint-Antoine [AP-HP]
Thy, Michael [Auteur]
AP-HP - Hôpital Bichat - Claude Bernard [Paris]
Bauvois, Adeline [Auteur]
Service de médecine interne [CHU Ambroise Paré]
Laureillard, Didier [Auteur]
Hôpital Universitaire Carémeau [Nîmes] [CHU Nîmes]
Hamrouni, Fadia [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Algarte-Genin, Michèle [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Poissy, Julien [Auteur]
Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Descamps, Diane [Auteur]
Infection, Anti-microbiens, Modélisation, Evolution [IAME (UMR_S_1137 / U1137)]
Costagliola, Dominique [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]

Journal title :

BMC Infectious Diseases

Abbreviated title :

BMC Infect Dis

Volume number :

22

Pages :

540

Publisher :

BioMed Central

Publication date :

2022-06-13

ISSN :

1471-2334

English keyword(s) :

COVID-19
SARS-CoV-2
Variant of concern Alpha
Severity

HAL domain(s) :

Sciences du Vivant [q-bio]
Chimie/Chimie théorique et/ou physique
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies infectieuses
Sciences du Vivant [q-bio]/Médecine humaine et pathologie/Maladies émergentes
Sciences du Vivant [q-bio]/Santé publique et épidémiologie

English abstract : [en]

Background: The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France. Methods: We conducted an exposed/unexposed cohort study with retrospective data ...
Show more >Background: The impact of the variant of concern (VOC) Alpha on the severity of COVID-19 has been debated. We report our analysis in France. Methods: We conducted an exposed/unexposed cohort study with retrospective data collection, comparing patients infected by VOC Alpha to contemporaneous patients infected by historical lineages. Participants were matched on age (± 2.5 years), sex and region of hospitalization. The primary endpoint was the proportion of hospitalized participants with severe COVID-19, defined as a WHO-scale > 5 or by the need of a non-rebreather mask, occurring up to day 29 after admission. We used a logistic regression model stratified on each matched pair and accounting for factors known to be associated with the severity of the disease. Results: We included 650 pairs of patients hospitalized between Jan 1, 2021, and Feb 28, 2021, in 47 hospitals. Median age was 70 years and 61.3% of participants were male. The proportion of participants with comorbidities was high in both groups (85.0% vs 90%, p = 0.004). Infection by VOC Alpha was associated with a higher odds of severe COVID-19 (41.7% vs 38.5%-aOR = 1.33 95% CI [1.03-1.72]). Conclusion: Infection by the VOC Alpha was associated with a higher odds of severe COVID-19.Show less >

Language :

Anglais

Peer reviewed article :

Oui

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694
• Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

Research team(s) :

Glycobiology in fungal Pathogenesis and Clinical Applications

Submission date :

2023-11-15T03:54:37Z
2024-01-16T13:11:35Z
2024-03-01T10:30:56Z