Title :

Heterogeneous SARS-CoV-2 humoral response after COVID-19 vaccination and/or infection in the general population.

Author(s) :

Carrat, Fabrice [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Villarroel, Paola Mariela Saba [Auteur]
Unité des Virus Emergents [UVE]
Lapidus, Nathanael [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Fourié, Toscane [Auteur]
Unité des Virus Emergents [UVE]
Blanché, Hélène [Auteur]
Centre d'Etude du Polymorphisme Humain [CEPH]
Dorival, Céline [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Nicol, Jérôme [Auteur]
Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
Deleuze, Jean‑François [Auteur]
Fondation Jean Dausset - Centre d’Etudes du Polymorphisme Humain [Paris] [CEPH]
Robineau, Olivier [Auteur]
METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Journal title :

Scientific Reports

Abbreviated title :

Sci Rep

Volume number :

12

Pages :

8622

Publication date :

2022-05-26

ISSN :

2045-2322

HAL domain(s) :

Sciences du Vivant [q-bio]

English abstract : [en]

Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the ...
Show more >Assessment of the intensity, dynamics and determinants of the antibody response after SARS-CoV-2 infection or vaccination in the general population is critical to guide vaccination policies. This study characterized the anti-spike IgG titers in 13,971 participants included in a French multicohort population-based serological survey on COVID-19 between April and October 2020 and followed-up with serological testing between May and October 2021. Eight follow-up profiles were defined depending on SARS-CoV-2 infection (0, 1 or 2) and COVID-19 vaccination (0, 1, 2 or 3). The anti-spike titer was lower in adults with no vaccination even in case of infection or reinfection, while it was higher in adults with infection followed by vaccination. The anti-spike titer was negatively correlated with age in vaccinated but uninfected adults, whereas it was positively correlated with age in unvaccinated but infected adults. In adults with 2 vaccine injections and no infection, the vaccine protocol, age, gender, and time since the last vaccine injection were independently associated with the anti-spike titer. The decrease in anti-spike titer was much more rapid in vaccinated than in infected subjects. These results highlight the strong heterogeneity of the antibody response against SARS-CoV-2 in the general population depending on previous infection and vaccination.Show less >

Language :

Anglais

Audience :

Internationale

Popular science :

Non

Administrative institution(s) :

Université de Lille
CHU Lille

Collections :

• METRICS : Evaluation des technologies de santé et des pratiques médicales - ULR 2694

Submission date :

2023-11-15T04:08:22Z
2023-12-08T10:25:13Z